Select a medication above to begin.
Tegretol XR
carbamazepine
Black Box Warnings .
Serious Dermatologic Rxns and HLA-B*15:02 Allele
serious, sometimes fatal dermatologic rxns reported, incl. toxic epidermal necrolysis and Stevens-Johnson syndrome; risk 10x greater in some Asian countries; strong assoc. between risk and HLA-B*15:02 allele, which is found almost exclusively in Asian pts; screen pts of genetically at-risk ancestry (see pkg insert) for HLA-B*15:02 allele before initiating tx; pts testing positive should not be treated w/ carbamazepine unless benefit clearly outweighs risk
Aplastic Anemia/Agranulocytosis
risk 5-8x greater than that of general public but low overall risk in untreated general population; transient or persistent decr. platelet or WBC counts not uncommon w/ carbamazepine tx but majority of leukopenia cases do not progress to aplastic anemia or agranulocytosis; perform baseline and periodic hematological testing; if low or decr. WBC or platelet counts monitor closely, consider D/C tx if evidence of significant bone marrow depression
Adult Dosing .
Dosage forms: ER TAB: 100 mg, 200 mg, 400 mg
seizure disorder
- [400-600 mg PO bid]
- Start: 200 mg PO bid, incr. by 200 mg/day qwk; Max: 1600 mg/day; Info: adjust dose based on tx response and serum levels; do not cut/crush/chew tab; taper dose gradually to D/C
trigeminal neuralgia
- [200-400 mg PO bid]
- Start: 100 mg PO bid, may incr. by 200 mg/day; Max: 1200 mg/day; Info: adjust dose based on tx response and serum levels; do not cut/crush/chew tab; taper dose gradually to D/C
renal dosing
- [adjust dose amount]
- CrCl <10: decr. usual dose by 25%
- HD: decr. usual dose by 25%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 25%; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: ER TAB: 100 mg, 200 mg, 400 mg
seizure disorder
- [6-12 yo]
- Dose: 200-400 mg PO bid; Start: 100 mg PO bid, incr. by 100 mg/day qwk; Max: 1000 mg/day; Info: adjust dose based on tx response and serum levels; do not cut/crush/chew tab; taper dose gradually to D/C
- [12-15 yo]
- Dose: 400 mg PO bid; Start: 200 mg PO bid, incr. by 200 mg/day qwk; Max: 1000 mg/day; Info: adjust dose based on tx response and serum levels; do not cut/crush/chew tab; taper dose gradually to D/C
- [>15 yo]
- Dose: 400-600 mg PO bid; Start: 200 mg PO bid, incr. by 200 mg/day qwk; Max: 1200 mg/day; Info: adjust dose based on tx response and serum levels; do not cut/crush/chew tab; taper dose gradually to D/C
renal dosing
- [adjust dose amount]
- CrCl <10: decr. usual dose by 25%
- HD: decr. usual dose by 25%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 25%; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised