guanfacine

Adult Dosing .

Dosage forms:  TAB: 1 mg, 2 mg

HTN

[0.5-2 mg PO qhs]

Start: 1 mg PO qhs, may incr. to 2 mg PO qhs after 3-4wk; Max: 3 mg/day; Info: taper dose over 4-7 days to D/C

opioid withdrawal (off-label)

[3-4 mg/day PO divided tid]

Info: taper dose over 4-7 days to D/C

Tourette syndrome (off-label)

[0.5-2 mg PO bid]

Start: 0.5 mg PO qd, titrate slowly; Max: 4 mg/day; Info: taper dose over 4-7 days to D/C

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 1 mg, 2 mg; ER TAB: 1 mg, 2 mg, 3 mg, 4 mg

ADHD

[extended-release form, 6-17 yo, 25-33.9 kg]

Dose: 2-3 mg ER PO qd; Start: 1 mg ER PO qd, incr. by 1 mg/day qwk; Alt: 0.05-0.12 mg/kg/dose ER PO qd; Info: for monotherapy or adjunct tx; do not give w/ high fat meals; do not cut/crush/chew ER tab; taper dose by 1 mg/day q3-7 days to D/C

[extended-release form, 6-17 yo, 34-41.4 kg]

Dose: 2-4 mg ER PO qd; Start: 1 mg ER PO qd, incr. by 1 mg/day qwk; Alt: 0.05-0.12 mg/kg/dose ER PO qd; Info: for monotherapy or adjunct tx; do not give w/ high fat meals; do not cut/crush/chew ER tab; taper dose by 1 mg/day q3-7 days to D/C

[extended-release form, 6-17 yo, 41.5-49.4 kg]

Dose: 3-5 mg ER PO qd; Start: 1 mg ER PO qd, incr. by 1 mg/day qwk; Alt: 0.05-0.12 mg/kg/dose ER PO qd; Info: for monotherapy or adjunct tx; do not give w/ high fat meals; do not cut/crush/chew ER tab; taper dose by 1 mg/day q3-7 days to D/C

[extended-release form, 6-17 yo, 49.5-58.4 kg]

Dose: 3-6 mg ER PO qd; Start: 1 mg ER PO qd, incr. by 1 mg/day qwk; Alt: 0.05-0.12 mg/kg/dose ER PO qd; Info: for monotherapy or adjunct tx; do not give w/ high fat meals; do not cut/crush/chew ER tab; taper dose by 1 mg/day q3-7 days to D/C

[extended-release form, 6-17 yo, 58.5-91 kg]

Dose: 4-7 mg ER PO qd; Start: 1 mg ER PO qd, incr. by 1 mg/day qwk; Alt: 0.05-0.12 mg/kg/dose ER PO qd; Info: for monotherapy or adjunct tx; do not give w/ high fat meals; do not cut/crush/chew ER tab; taper dose by 1 mg/day q3-7 days to D/C

[extended-release form, 6-17 yo, >91 kg]

Dose: 5-7 mg ER PO qd; Start: 1 mg ER PO qd, incr. by 1 mg/day qwk; Alt: 0.05-0.12 mg/kg/dose ER PO qd; Info: for monotherapy or adjunct tx; do not give w/ high fat meals; do not cut/crush/chew ER tab; taper dose by 1 mg/day q3-7 days to D/C

[immediate-release form, 27-40.5 kg (off-label)]

Dose: 0.5 mg PO bid-qid; Start: 0.5 mg PO qhs, then may incr. by 0.5 mg/day qwk up to 1.5 mg/day, then may incr. to 2 mg/day after 2wk; Max: 0.5 mg/dose, 2 mg/day; Info: taper dose over 4-7 days to D/C

[immediate-release form, 40.5-45 kg (off-label)]

Dose: 0.5 mg PO bid-qid; Start: 0.5 mg PO qhs, then may incr. by 0.5 mg/day qwk up to 1.5 mg/day, then may incr. by 0.5 mg/day q2wk; Max: 1 mg/dose, 3 mg/day; Info: taper dose over 4-7 days to D/C

[immediate-release form, >45 kg (off-label)]

Dose: 1 mg PO bid-qid; Start: 1 mg PO qhs, then may incr. by 1 mg/day qwk up to 3 mg/day, then may incr. to 4 mg/day after 2wk; Max: 1 mg/dose, 4 mg/day; Info: taper dose over 4-7 days to D/C

Tourette syndrome (off-label)

[6 yo and older]

Dose: 1-4 mg/day PO divided bid-tid; Start: 0.25 mg PO qd, titrate slowly; Max: 4 mg/day; Info: taper dose over 4-7 days to D/C

renal dosing

[extended-release form]

renal impairment: not defined; Info: consider decr. usual dose if significant impairment

HD/PD: not defined

[immediate-release form]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[extended-release form]

hepatic impairment: not defined; Info: consider decr. usual dose if significant impairment

[immediate-release form]

hepatic impairment: not defined, caution advised