Trecator

Adult Dosing .

Dosage forms:  TAB: 250 mg

tuberculosis, active

[15-20 mg/kg/day PO divided qd-bid]

Start: 250 mg PO qd x1-2 days, then 250 mg bid x1-2 days; Max: 1000 mg/day; Info: part of multi-drug regimen; not 1st-line agent; give w/ food

renal dosing

[adjust dose amount, frequency]

CrCl <30: 250-500 mg qd

HD: 250-500 mg qd, on dialysis days admin. after dialysis; no supplement; PD: not defined

hepatic dosing

[see below]

severe impairment: contraindicated

Peds Dosing .

Dosage forms:  TAB: 250 mg

tuberculosis, active (off-label)

[2-14 yo]

Dose: 15-20 mg/kg/day PO divided qd-bid; Start: 250 mg PO qd x1-2 days, then 250 mg bid x1-2 days; Max: 750 mg/day; Info: part of multi-drug regimen; not 1st-line agent; give w/ food

[15 yo and older]

Dose: 15-20 mg/kg/day PO divided qd-bid; Start: 250 mg PO qd x1-2 days, then 250 mg bid x1-2 days; Max: 750 mg/day; Info: part of multi-drug regimen; not 1st-line agent; give w/ food

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance