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amiloride
generic
Black Box Warnings .
Hyperkalemia
hyperkalemia risk, potentially fatal if uncorrected; 10% incidence if not used w/ kaliuretic diuretic; incr. incidence in renal impairment, diabetes (even w/out recognized diabetic nephropathy) and elderly pts; risk decr. to 1-2% in combo w/ thiazide diuretics; monitor K at tx start, dose change, and during illness affecting renal fxn
Adult Dosing .
Dosage forms: TAB: 5 mg
HTN, adjunct tx
- [5-10 mg PO qd]
- Max: 20 mg/day; Info: give w/ food
heart failure, adjunct tx
- [5-10 mg PO qd]
- Max: 20 mg/day; Info: give w/ food
lithium-induced polyuria (off-label)
- [5-10 mg PO bid]
renal dosing
- [see below]
- renal impairment/anuria: contraindicated; Info: caution advised if BUN >30 or Cr >1.5
- HD/PD: avoid use
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.