Select a medication above to begin.
perphenazine/ amitriptyline
generic
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds use
Adult Dosing .
Dosage forms: TAB: 2 mg/10 mg, 2 mg/25 mg, 4 mg/10 mg, 4 mg/25 mg, 4 mg/50 mg
depression w/ anxiety
- [1 tab PO bid-qid]
- Max: 32 mg/200 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC; taper dose gradually to D/C
psychosis w/ depression
- [1 tab PO bid-qid]
- Max: 32 mg/200 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC; taper dose gradually to D/C
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.