cefpodoxime proxetil

Adult Dosing .

Dosage forms:  TAB: 100 mg, 200 mg; SUSP: 50 mg per 5 mL, 100 mg per 5 mL

infections, bacterial

[100-400 mg PO bid]

Info: duration varies by infection site/severity; give tabs w/ food

chronic bronchitis, acute bacterial exacerbation

[200 mg PO bid x10 days]

Info: give tabs w/ food

pneumonia, community-acquired

[200 mg PO bid for at least 5 days]

Info: part of multi-drug regimen; refer to IDSA guidelines; give tabs w/ food

UTI, uncomplicated

[100 mg PO bid x3-7 days]

Info: not 1st-line agent; give tabs w/ food

renal dosing

[adjust dose frequency]

CrCl <30: give usual dose q24h

HD: give usual dose 3x/wk after dialysis; no supplement; PD: give usual dose q24h; no supplement

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  TAB: 100 mg, 200 mg; SUSP: 50 mg per 5 mL, 100 mg per 5 mL

infections, bacterial

[2 mo-11 yo]

Dose: 10 mg/kg/day PO divided q12h x5-10 days; Max: 400 mg/day; Info: give tabs w/ food

[12 yo and older]

Dose: 100-400 mg PO bid x7-14 days; Info: give tabs w/ food

otitis media, acute

[2 mo-1 yo]

Dose: 10 mg/kg/day susp PO divided q12h x10 days; Max: 400 mg/day

[mild-moderate infection, 2-5 yo]

Dose: 10 mg/kg/day PO divided q12h x7 days; Max: 400 mg/day; Info: give tabs w/ food

[mild-moderate infection, 6-12 yo]

Dose: 10 mg/kg/day PO divided q12h x5-7 days; Max: 400 mg/day; Info: give tabs w/ food

[severe infection, 2-12 yo]

Dose: 10 mg/kg/day PO divided q12h x10 days; Max: 400 mg/day; Info: give tabs w/ food

chronic bronchitis, acute bacterial exacerbation

[12 yo and older]

Dose: 200 mg PO q12h x10 days; Info: give tabs w/ food

UTI

[2 mo-11 yo (off-label)]

Dose: 10 mg/kg/day PO divided q12h x7-14 days; Max: 400 mg/day; Info: duration varies w/ infection type, severity; give tabs w/ food

[12 yo and older]

Dose: 100 mg PO bid x7 days; Info: for uncomplicated UTI; give tabs w/ food

pneumonia, community-acquired (off-label)

[3 mo-11 yo]

Dose: 10 mg/kg/day PO divided q12h x10 days; Max: 200 mg/dose; Info: refer to IDSA guidelines; give tabs w/ food

[12 yo and older]

Dose: 200 mg PO bid x10 days; Info: refer to IDSA guidelines; give tabs w/ food

renal dosing

[adjust dose frequency]

CrCl <30: give usual divided dose q24h

HD: give usual divided dose 3x/wk after dialysis; no supplement; PD: give usual divided dose q24h; no supplement

hepatic dosing

[no adjustment]