enalapril

Adult Dosing .

Dosage forms:  TAB: 2.5 mg, 5 mg, 10 mg, 20 mg; SOL: 1 mg per mL

HTN

[5-40 mg/day PO divided qd-bid]

Start: 5 mg PO qd; Max: 40 mg/day; Info: start 2.5 mg PO qd if on diuretic

heart failure w/ reduced ejection fraction

[10-20 mg PO bid]

Start: 2.5 mg PO bid, may incr. dose q1-2wk; Max: 40 mg/day; Info: start 2.5 mg PO qd if hyponatremia

left ventricular dysfxn, asymptomatic

[10 mg PO bid]

Start: 2.5 mg PO bid; Max: 20 mg/day

MI, acute (off-label)

[10 mg PO bid]

Start: 2.5 mg PO qd w/in 48h post-MI, quickly titrate dose up

nephropathy (off-label)

[5-20 mg/day PO divided qd-bid]

renal dosing

[HTN]

CrCl <31: start 2.5 mg qd

HD: start 2.5 mg after dialysis on dialysis days; no supplement; PD: start 2.5 mg on dialysis days; supplement not defined; Info: titrate dose to target BP on non-dialysis days

[heart failure w/ reduced ejection fraction]

Cr >1.6: start 2.5 mg qd

HD/PD: not defined

[all other indications]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 2.5 mg, 5 mg, 10 mg, 20 mg; SOL: 1 mg per mL

HTN

[1 mo and older]

Dose: 0.1-0.5 mg/kg/day PO divided q12-24h; Start: 0.08 mg/kg/day up to 5 mg/day PO divided q12-24h; Max: 0.58 mg/kg/day up to 40 mg/day

heart failure w/ reduced ejection fraction (off-label)

[1 mo and older]

Dose: 0.1-0.5 mg/kg/day PO divided q12-24h; Start: 0.08 mg/kg/day PO divided q12-24h, titrate dose slowly over 2wk; Max: 40 mg/day

renal dosing

[see below]

CrCl <30: avoid use

HD/PD: not defined, consider adult renal dosing for guidance

hepatic dosing

[not defined]