amoxicillin

Adult Dosing .

Dosage forms:  CAP: 250 mg, 500 mg; TAB: 500 mg, 875 mg; ER TAB: 775 mg; CHEWABLE: 125 mg, 250 mg; SUSP: 125 mg per 5 mL, 200 mg per 5 mL, 250 mg per 5 mL, 400 mg per 5 mL

infections, bacterial

[500-875 mg PO q12h]

Alt: 250-500 mg PO q8h; Info: dose, duration vary by infection type/severity

pharyngitis, streptococcal

[immediate-release form]

Dose: 1000 mg PO q24h x10 days; Alt: 500 mg PO q12h x10 days

[extended-release form]

Dose: 775 mg ER PO q24h x10 days; Info: give w/ in 1h of a meal; do not cut/crush/chew ER tab

sinusitis, acute bacterial

[1 g PO q8h x5-10 days]

Max: 4 g/day; Alt: 1.5-4 g/day PO divided q6-8h x5-10 days; Info: not recommended per IDSA guidelines

H. pylori infection

[triple tx]

Dose: 1 g PO bid-tid x14 days; Info: part of multi-drug regimen; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

[dual tx]

Dose: 1 g PO tid x14 days; Info: give w/ vonoprazan or PPI; PPI regimen not 1st-line tx; dosing may vary; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

pneumonia, community-acquired

[1 g PO q8h for at least 5 days]

Info: refer to IDSA guidelines

endocarditis prophylaxis, dental (off-label)

[2 g PO x1]

Start: 30-60min before procedure; Info: see Infectious Disease: Endocarditis Prophylaxis, Adult table

anthrax (off-label)

[cutaneous]

Dose: 1 g PO q8h x7-10 days; Info: for non-systemic infection w/ penicillin-susceptible B. anthracis; not 1st-line agent; use extended duration for post-exposure prophylaxis if bioterrorism suspected

[post-exposure prophylaxis]

Dose: 1 g PO q8h x60 days; Info: for penicillin-susceptible B. anthracis; not 1st-line agent; give in combo w/ anthrax vaccine; may use to complete course for systemic infection; may give x42 days or x14 days after last vaccine dose in immunocompetent pts 18-65 yo if anthrax vaccine regimen completed

infections, chlamydial (off-label)

[pregnant pts]

Dose: 500 mg PO q8h x7 days; Info: not 1st-line agent

dental abscess (off-label)

[1 g PO x1, then 500 mg PO q8h x3 days]

Info: use w/ incision, drainage

Lyme dz (off-label)

[500 mg PO q8h x14-21 days]

Info: for non-neurologic dz; give x14 days if early, localized dz; extend duration to 28 days if Lyme arthritis; 1st-line agent; search 'Lyme' for epocrates Lyme Disease Dx & Tx decision tool

salmonellosis, acute (off-label)

[immunocompetent pts]

Dose: 500 mg PO q8h x3-7 days; Info: not 1st-line tx

[immunocompromised pts]

Dose: 1 g PO q8h x3-14 days; Info: not 1st-line tx

salmonella, chronic carrier (off-label)

[1 g PO q8h x3mo]

Info: not 1st-line tx

typhoid fever (off-label)

[50-100 mg/kg/day PO divided q6-8h x14 days]

Info: not 1st-line tx

renal dosing

[immediate-release form]

CrCl 10-30: 250-500 mg q12h; CrCl <10: 250-500 mg q24h; Info: do not use 875 mg tab for CrCl <30

HD: 250-500 mg q24h, on dialysis days admin. after dialysis; consider supplement during and after dialysis if next maint. dose not due right after dialysis; PD: 250 mg q12h; no supplement; Info: do not use 875 mg tab for CrCl <30

[extended-release form]

CrCl <30: avoid use

HD/PD: avoid use

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  CAP: 250 mg, 500 mg; TAB: 500 mg, 875 mg; ER TAB: 775 mg; CHEWABLE: 125 mg, 250 mg; SUSP: 125 mg per 5 mL, 200 mg per 5 mL, 250 mg per 5 mL, 400 mg per 5 mL

infections, bacterial

[0-3 mo]

Dose: 20-30 mg/kg/day PO divided q12h; Max: 30 mg/kg/day; Info: dose, duration vary by infection type/severity

[>3 mo]

Dose: 25-45 mg/kg/day PO divided q12h; Max: 875 mg/dose; Alt: 20-40 mg/kg/day PO divided q8h; Info: dose, duration vary by infection type/severity

otitis media, acute

[6 mo-1 yo]

Dose: 80-90 mg/kg/day PO divided q12h x10 days

[mild-moderate infection, 2-5 yo]

Dose: 80-90 mg/kg/day PO divided q12h x7 days

[mild-moderate infection, 6-12 yo]

Dose: 80-90 mg/kg/day PO divided q12h x5-7 days

[severe infection, 2-12 yo]

Dose: 80-90 mg/kg/day PO divided q12h x10 days

community-acquired pneumonia, mild-moderate bacterial

[3 mo-4 yo]

Dose: 90 mg/kg/day PO divided q12h x5-10 days

[5 yo and older]

Dose: 90 mg/kg/day PO divided q12h x5-10 days; Max: 4000 mg/day

pharyngitis, streptococcal

[immediate-release form]

Dose: 50 mg/kg/dose PO q24h x10 days; Max: 1000 mg/day; Alt: 25 mg/kg/dose PO q12h x10 days

[extended-release form, 12 yo and older]

Dose: 775 mg ER PO q24h x10 days; Info: give w/ in 1h of a meal; do not cut/crush/chew ER tab

sinusitis, acute bacterial

[>3 mo]

Dose: 90 mg/kg/day PO divided q8-12h x10 days; Max: 1000 mg/dose; Info: not recommended per IDSA guidelines

H. pylori infection (off-label)

[15-24 kg]

Dose: 500 mg PO bid x10-14 days; Info: part of multi-drug regimen, dosing may vary; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

[25-34 kg]

Dose: 750 mg PO bid x10-14 days; Info: part of multi-drug regimen, dosing may vary; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

[>35 kg]

Dose: 1 g PO bid x10-14 days; Info: part of multi-drug regimen, dosing may vary; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

endocarditis prophylaxis, dental (off-label)

[50 mg/kg/dose PO x1]

Start: 30-60min before procedure; Info: see Infectious Disease: Endocarditis Prophylaxis, Pediatric table

anthrax, cutaneous (off-label)

[neonates >32 wk gestation]

Dose: 50-75 mg/kg/day PO divided q8-12h x7-10 days; Info: for penicillin-susceptible B. anthracis non-systemic infection; dose, frequency depend on gestational and post-natal age; give abx x60 days total if bioterrorism suspected

[1 mo and older]

Dose: 75 mg/kg/day PO divided q8h x7-10 days; Max: 1 g/dose; Info: for penicillin-susceptible B. anthracis non-systemic infection; give abx x60 days total if bioterrorism suspected

anthrax, post-exposure prophylaxis

[neonates >32 wk gestation]

Dose: 50-75 mg/kg/day PO divided q8-12h x60 days; Info: for penicillin-susceptible B. anthracis exposure; dose, frequency depend on gestational and post-natal age; may use to complete course for systemic infection

[1 mo and older]

Dose: 75 mg/kg/day PO divided q8h x60 days; Max: 1 g/dose; Info: for penicillin-susceptible B. anthracis exposure; may use to complete course for systemic infection

infections, chlamydial (off-label)

[pregnant pts, adolescents]

Dose: 500 mg PO q8h x7 days; Info: not 1st-line agent

Lyme dz (off-label)

[50 mg/kg/day PO divided q8h x14-21 days]

Max: 500 mg/dose; Info: for non-neurologic dz; give x14 days if early, localized dz; extend duration to 28 days if Lyme arthritis; 1st-line agent; search 'Lyme' for epocrates Lyme Disease Dx & Tx decision tool

salmonellosis, acute (off-label)

[>3 mo]

Dose: 50-100 mg/kg/day PO divided q8-12h x3-7 days; Info: may extend tx x1wk if immunocompromised; not 1st-line tx

salmonella, chronic carrier (off-label)

[>3 mo]

Dose: 50-100 mg/kg/day PO divided q8-12h x3mo; Info: not 1st-line tx

typhoid fever (off-label)

[>3 mo]

Dose: 50-100 mg/kg/day PO divided q6-8h x14 days; Info: not 1st-line tx

bacterial arthritis, acute (off-label)

[50-100 mg/kg/day PO divided q8h]

Info: duration varies by organism, infection severity

renal dosing

[immediate-release form]

CrCl 10-30: 16-40 mg/kg/day divided q12h; CrCl <10: 8-20 mg/kg/dose q24h; Info: do not use 875 mg tab if CrCl <30

HD: 8-20 mg/kg/dose q24h, on dialysis days admin. after dialysis; consider supplement during and after dialysis if next maint. dose not due right after dialysis; PD: 8-20 mg/kg/dose q24h; no supplement; Info: do not use 875 mg tab for CrCl <30

[extended-release form]

CrCl <30: avoid use

HD/PD: avoid use

hepatic dosing

[not defined]