Select a medication above to begin.
ampicillin
generic
Adult Dosing .
Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: PO ampicillin has generally been replaced by amoxicillin for the tx of many infections due to more reliable absorption and bioavailability
infections, bacterial
- [0.5-3 g IM/IV q4-6h]
- Max: 14 g/day; Info: dose, duration vary by infection type, severity
meningitis, bacterial
- [1-2 g IV q3-4h]
- Max: 14 g/day
GBS prophylaxis, intrapartum
- [1-2 g IV q4-6h]
- Start: 2 g IV x1 at least 4h prior to delivery
endocarditis treatment
- [2 g IV q4h x4-6wk]
- Info: duration varies w/ pathogen susceptibility, valve type, sx duration; may give w/ aminoglycoside gram positive synergy; refer to AHA guidelines
endocarditis prophylaxis, dental
- [2 g IM/IV x1]
- Start: 30-60min before procedure; Info: see Infectious Disease: Endocarditis Prophylaxis, Adult table
typhoid fever
- [50-100 mg/kg/day IV divided q6h x1-2wk]
anthrax, systemic (off-label)
- [3 g IV q6h for at least 2wk]
- Info: for penicillin-susceptible B. anthracis; not 1st-line agent; part of multi-drug regimen; switch to PO abx for post-exposure prophylaxis if inhalational exposure
renal dosing
- [see below]
- CrCl 10-50: give usual divided dose q6-12h; CrCl <10: give usual divided dose q12-24h
- HD: give usual divided dose q12-24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: give usual divided dose q12h; no supplement
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: PO ampicillin has generally been replaced by amoxicillin for the tx of many infections due to more reliable absorption and bioavailability
infections, bacterial
- [neonates <7 days old, <2 kg]
- Dose: 50-100 mg/kg/day IM/IV divided q12h; Info: dose, duration vary by infection type, severity
- [neonates <7 days old, >2 kg]
- Dose: 75-150 mg/kg/day IM/IV divided q8h; Info: dose, duration vary by infection type, severity
- [neonates 7 days old and older, <1.2 kg]
- Dose: 50-100 mg/kg/day IM/IV divided q12h; Info: dose, duration vary by infection type, severity
- [neonates 7 days old and older, 1.2-2 kg]
- Dose: 75-150 mg/kg/day IM/IV divided q8h; Info: dose, duration vary by infection type, severity
- [neonates 7 days old and older, >2 kg]
- Dose: 100-200 mg/kg/day IM/IV divided q6h; Info: dose, duration vary by infection type, severity
- [infants/children]
- Dose: 100-400 mg/kg/day IM/IV divided q4-6h; Max: 12 g/day IM/IV; Info: dose, duration vary by infection type, severity
community-acquired pneumonia, severe bacterial
- [>3 mo]
- Dose: 150-400 mg/kg/day IV divided q6h x10 days; Info: may switch to PO regimen when possible to complete course
meningitis, Group B Streptococcal
- [neonates <7 days old]
- Dose: 200-300 mg/kg/day IV divided q8h x14-21 days
- [neonates 7 days old and older]
- Dose: 300 mg/kg/day IV divided q6h x14-21 days
meningitis, non-Group B Streptococcal
- [neonates <7 days old, <2 kg]
- Dose: 100 mg/kg/day IV divided q12h; Info: duration varies by organism, infection severity
- [neonates <7 days old, >2 kg]
- Dose: 150 mg/kg/day IV divided q8h; Info: duration varies by organism, infection severity
- [neonates 7 days old and older, <1.2 kg]
- Dose: 100 mg/kg/day IV divided q12h; Info: duration varies by organism, infection severity
- [neonates 7 days old and older, 1.2-2 kg]
- Dose: 150 mg/kg/day IV divided q8h; Info: duration varies by organism, infection severity
- [neonates 7 days old and older, >2 kg]
- Dose: 200 mg/kg/day IV divided q6h; Info: duration varies by organism, infection severity
- [infants/children]
- Dose: 200-400 mg/kg/day IV divided q4-6h; Max: 12 g/day; Info: dose, duration vary by organism, infection severity
endocarditis treatment
- [200-300 mg/kg/day IV divided q4-6h x4-6wk]
- Max: 12 g/day; Info: duration varies by pathogen susceptibility; give w/ aminoglycoside gram positive synergy; refer to AHA guidelines
endocarditis prophylaxis, dental
- [50 mg/kg/dose IM/IV x1]
- Start: 30-60min before procedure; Info: see Infectious Disease: Endocarditis Prophylaxis, Pediatric table
typhoid fever
- [100 mg/kg/day IV divided q6h x1-2wk]
anthrax, systemic (off-label)
- [neonates >32 wk gestation]
- Dose: 100-200 mg/kg/day IV divided q6-12h for at least 2wk; Info: for penicillin-susceptible B. anthracis; not 1st-line agent; part of multi-drug regimen; dose, frequency depend on gestational and post-natal age; switch to PO abx x60 days total if inhalational exposure
- [1 mo and older]
- Dose: 200 mg/kg/day IV divided q6h for at least 2wk; Max: 3 g/dose; Info: for penicillin-susceptible B. anthracis; not 1st-line agent; part of multi-drug regimen; switch to PO abx x60 days total if inhalational exposure
renal dosing
- [if q4-6h usual frequency]
- CrCl 10-30: give usual divided dose q8h; CrCl <10: give usual divided dose q12h
- HD: give usual divided dose q12h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: give usual divided dose q12h; no supplement
- [if q8-12h usual frequency]
- renal impairment: consider decr. usual frequency
- HD: consider decr. usual frequency, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: consider decr. usual frequency; no supplement
hepatic dosing
- [not defined]