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Wellbutrin SR
bupropion hydrochloride
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber
Adult Dosing .
Dosage forms: ER TAB: 100 mg, 150 mg, 200 mg
major depressive disorder
- [150 mg PO bid]
- Start: 150 mg PO qam, may incr. to 150 mg PO bid after 3 days; Max: 200 mg/dose up to 400 mg/day; Info: separate doses by at least 8h; do not cut/crush/chew tab
smoking cessation (off-label)
- [150 mg PO bid x7-12wk]
- Start: 150 mg PO qd, incr. to 150 mg PO bid after 3 days; Max: 300 mg/day; Info: separate doses by at least 8h; last dose no later than 6pm; stop smoking after 5-7 days of tx; do not cut/crush/chew tab
ADHD (off-label)
- [200 mg PO qam, 100 mg PO qpm]
- Start: 100 mg PO qam, may incr. by 100 mg/day qwk, divide dose bid; Max: 400 mg/day; Info: separate doses by at least 8h; do not cut/crush/chew tab
renal dosing
- [see below]
- renal impairment: consider decr. usual dose and/or frequency; Info: ER form cannot be cut, consider IR form for dose adjustments
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A: consider decr. usual dose and/or frequency; Child-Pugh Class B or C: max 100 mg/day or 150 mg q48h
Peds Dosing .
- Dosage forms: ER TAB: 100 mg, 150 mg, 200 mg
major depressive disorder (off-label)
- [11 yo and older]
- Dose: 3-6 mg/kg/day PO divided bid; Start: 2 mg/kg/dose up to 100 mg PO qam, may incr. by up to 1 mg/kg/day q2-3wk; Max: 150 mg/dose; Info: not 1st line tx; separate doses by at least 8h; do not cut/crush/chew tab
ADHD (off-label)
- [11 yo and older]
- Dose: 3-6 mg/kg/day PO divided bid; Start: 2 mg/kg/dose up to 100 mg PO qam, may incr. by up to 1 mg/kg/day q2-3wk; Max: 150 mg/dose; Info: separate doses by at least 8h; do not cut/crush/chew tab
smoking cessation (off-label)
- [14 yo and older, >40.5 kg]
- Dose: 150 mg PO bid x7-12wk; Start: 150 mg PO qd, incr. to 150 mg PO bid after 3 days; Max: 300 mg/day; Info: separate doses by at least 8h; last dose no later than 6pm; stop smoking after 5-7 days of tx; do not cut/crush/chew tab
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: not defined
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance