tizanidine

Adult Dosing .

Dosage forms:  CAP: 2 mg, 4 mg, 6 mg; TAB: 2 mg, 4 mg

Special Note

[formulation clarification]

Info: cap and tab bioequivalent only if fasting, not bioequivalent if fed; caution advised if switching between formulations

spasticity

[individualize dose PO q6-8h prn]

Start: 2 mg PO q6-8h prn for up to 3 doses/24h, may incr. by 2-4 mg/dose q1-4 days; Max: 36 mg/day; Info: give consistently w/ food or on empty stomach; taper dose by 2-4 mg/day to D/C if prolonged, high-dose use

renal dosing

[adjust dose amount]

CrCl <25: decr. usual dose, amount not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

hepatic impairment: decr. usual dose, amount not defined

Peds Dosing .

Dosage forms:  CAP: 2 mg, 4 mg, 6 mg; TAB: 2 mg, 4 mg

Special Note

[formulation clarification]

Info: cap and tab bioequivalent only if fasting, not bioequivalent if fed; caution advised if switching between formulations

spasticity (off-label)

[2-9 yo]

Dose: 0.3-0.5 mg/kg/day PO divided tid-qid; Start: 1 mg PO qhs, may incr. dose q1-4 days; Max: 24 mg/day; Info: give consistently w/ food or on empty stomach; taper dose to D/C if prolonged, high-dose use

[10 yo and older]

Dose: 0.3-0.5 mg/kg/day PO divided tid-qid; Start: 2 mg PO qhs, may incr. dose q1-4 days; Max: 24 mg/day; Info: give consistently w/ food or on empty stomach; taper dose to D/C if prolonged, high-dose use

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance