Zocor

Adult Dosing .

Dosage forms:  TAB: 10 mg, 20 mg, 40 mg

Special Note

[restricted 80 mg dose]

Info: max simvastatin dose 40 mg/day; as of 6/8/2011, any pt previously on 80 mg/day w/o muscle toxicity x12mo may remain on this dose; do not incr. dose to 80 mg/day in any other pts; switch to alternative tx if LDL-C goal not met on 40 mg/day

primary hyperlipidemia

[10-40 mg PO qpm]

Max: 40 mg/day; Info: may adjust dose q4wk; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

heterozygous familial hypercholesterolemia

[10-40 mg PO qpm]

Max: 40 mg/day; Info: may adjust dose q4wk; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

homozygous familial hypercholesterolemia, adjunct tx

[10-40 mg PO qpm]

Max: 40 mg/day; Info: may adjust dose q4wk; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

hypertriglyceridemia

[10-40 mg PO qpm]

Max: 40 mg/day; Info: may adjust dose q4wk; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

primary dysbetalipoproteinemia

[10-40 mg PO qpm]

Max: 40 mg/day; Info: may adjust dose q4wk; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

cardiovascular event risk reduction

[10-40 mg PO qpm]

Max: 40 mg/day; Info: may adjust dose q4wk; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

atherosclerotic cardiovascular dz

[10-40 mg PO qpm]

Max: 40 mg/day; Info: may adjust dose q4wk; search 'cholesterol' for epocrates Adult Cholesterol Tx Selector decision tool

renal dosing

[adjust dose amount]

CrCl 15-29: start 5 mg qpm; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

acute hepatic failure or decompensated cirrhosis: contraindicated

Peds Dosing .

Dosage forms:  TAB: 10 mg, 20 mg, 40 mg

Special Note

[restricted 80 mg dose]

Info: max simvastatin dose 40 mg/day; as of 6/8/2011, any pt previously on 80 mg/day w/o muscle toxicity x12mo may remain on this dose; do not incr. dose to 80 mg/day in any other pts; switch to alternative tx if LDL-C goal not met on 40 mg/day

heterozygous familial hypercholesterolemia

[10 yo and older]

Dose: 10-40 mg PO qpm; Max: 40 mg/day; Info: may adjust dose q4wk

homozygous familial hypercholesterolemia, adjunct tx (off-label)

[10 yo and older]

Dose: 20-40 mg PO qpm; Max: 40 mg/day; Info: may adjust dose q4wk

renal dosing

[adjust dose amount]

CrCl 15-29: start 5 mg qpm; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

acute hepatic failure or decompensated cirrhosis: contraindicated