Select a medication above to begin.
sertraline
generic
Black Box Warnings .
Suicidality
antidepressants incr. suicidality risk in peds and young adult pts in short-term studies; monitor closely for clinical worsening and suicidality; advise families and caregivers of need for close observation and communication w/ prescriber
Adult Dosing .
Dosage forms: CAP: 150 mg, 200 mg; TAB: 25 mg, 50 mg, 100 mg; SOL: 20 mg per mL
major depressive disorder
- [50-200 mg PO qd]
- Start: 50 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
obsessive-compulsive disorder
- [50-200 mg PO qd]
- Start: 50 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
panic disorder
- [50-200 mg PO qd]
- Start: 25 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
post-traumatic stress disorder
- [50-200 mg PO qd]
- Start: 25 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
premenstrual dysphoric disorder
- [daily dosing]
- Dose: 50-150 mg PO qd; Start: 50 mg PO qd, may incr. by 50 mg/day w/ each menstrual cycle; Max: 150 mg/day; Info: taper dose gradually to D/C; do not open cap
- [luteal phase dosing]
- Dose: 50-100 mg PO qd during luteal phase; Start: 50 mg PO qd during luteal phase; Max: 100 mg/day; Info: if inadequate response w/ 50 mg PO qd, may give 50 mg PO qd x3 days, then incr. to 100 mg PO qd w/ each luteal phase dosing cycle
social anxiety disorder
- [50-200 mg PO qd]
- Start: 25 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- Child-Pugh Class A: decr. usual dose by 50%; Child-Pugh Class B or C: avoid use
Peds Dosing .
- Dosage forms: CAP: 150 mg, 200 mg; TAB: 25 mg, 50 mg, 100 mg; SOL: 20 mg per mL
obsessive-compulsive disorder
- [6-12 yo]
- Dose: 50-200 mg PO qd; Start: 25 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
- [13-17 yo]
- Dose: 50-200 mg PO qd; Start: 50 mg PO qd, may incr. by 25-50 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
major depressive disorder (off-label)
- [10 yo and older]
- Dose: 25-200 mg PO qd; Start: 25 mg PO qd, may incr. by 12.5-25 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C; do not open cap
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- Child-Pugh Class A: decr. usual dose by 50%; Child-Pugh Class B or C: avoid use