amphotericin B liposomal

Adult Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: amphotericin B salts, liposomal, and lipid-complex products not bioequivalent; reassess dose if switching between products

infections, systemic fungal

[3-5 mg/kg/dose IV q24h]

febrile neutropenia

[3 mg/kg/dose IV q24h]

Info: may give up to 5 mg/kg/dose IV q24h if persistent or relapsed fever

meningitis, cryptococcal

[6 mg/kg/dose IV q24h x11-21 days]

visceral leishmaniasis

[immunocompetent pts]

Dose: 3 mg/kg/dose IV q24h on days 1-5, 14, 21

[immunocompromised pts]

Dose: 4 mg/kg/dose IV q24h on days 1-5, 10, 17, 24, 31, 38

endocarditis, fungal (off-label)

[3-5 mg/kg/dose IV q24h]

Info: cont. for >6wk; refer to AHA guidelines

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: amphotericin B salts, liposomal, and lipid-complex products not bioequivalent; reassess dose if switching between products

infections, systemic fungal

[1 mo and older]

Dose: 3-5 mg/kg/dose IV q24h

febrile neutropenia

[1 mo and older]

Dose: 3 mg/kg/dose IV q24h; Info: may give up to 5 mg/kg/dose IV q24h if persistent or relapsed fever

meningitis, cryptococcal

[1 mo and older]

6 mg/kg/dose IV q24h x11-21 days

visceral leishmaniasis

[immunocompetent pts, 1 mo and older]

Dose: 3 mg/kg/dose IV q24h on days 1-5, 14, 21

[immunocompromised pts, 1 mo and older]

Dose: 4 mg/kg/dose IV q24h on days 1-5, 10, 17, 24, 31, 38

endocarditis, fungal (off-label)

[1 mo and older]

Dose: 3-5 mg/kg/dose IV q24h; Info: cont. for >6wk; refer to AHA guidelines

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]