cefazolin

Adult Dosing .

Dosage forms:  INJ

infections, bacterial

[2 g IM/IV q8h]

Max: 12 g/day; Info: duration varies w/ infection type, severity

infection prophylaxis, surgical

[<120 kg]

Dose: 2 g IV x1; Start: w/in 60min preop; Info: may repeat dose q4h intraop

[>120 kg]

Dose: 3 g IV x1; Start: w/in 60min preop; Info: may repeat dose q4h intraop

endocarditis treatment

[native valve]

Dose: 2 g IV q8h x4-6wk; Info: duration varies w/ pathogen susceptibility; refer to AHA guidelines

[prosthetic valve]

Dose: 2 g IV q8h for at least 6wk; Info: give w/ gentamicin gram positive synergy x2wk and rifampin; refer to AHA guidelines

endocarditis prophylaxis, dental

[1 g IM/IV x1]

Start: 30-60min before procedure; Info: see Infectious Disease: Endocarditis Prophylaxis, Adult table

renal dosing

[see below]

CrCl 11-34: give usual dose x1, then give 50% usual dose q12h; CrCl <10: give usual dose x1, then give 50% usual dose q24h

HD: 2 g x1 after dialysis if next dialysis due in 48h or 3 g x1 after dialysis if next dialysis due in 72h; no supplement; Alt: 0.5-1 g q24h, on dialysis days admin. after dialysis; consider 15-20 mg/kg/dose supplement if next maint. dose not due right after dialysis; PD: 0.5 g q12h; supplement not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

infections, bacterial

[<32 wk gestation, 0-6 days old]

Dose: 50 mg/kg/day IM/IV divided q12h; Info: duration varies w/ infection type, severity

[<32 wk gestation, 7-28 days old]

Dose: 75 mg/kg/day IM/IV divided q8h; Info: duration varies w/ infection type, severity

[>32 wk gestation, 0-7 days old]

Dose: 100 mg/kg/day IM/IV divided q12h; Info: duration varies w/ infection type, severity

[>32 wk gestation, 8-28 days old]

Dose: 150 mg/kg/day IM/IV divided q8h; Info: duration varies w/ infection type, severity

[1 mo and older]

Dose: 25-100 mg/kg/day IM/IV divided q6-8h; Max: 6 g/day; Info: dose, duration varies w/ infection type, severity

infection prophylaxis, surgical

[1 yo and older]

Dose: 30 mg/kg/dose IV x1; Start: w/in 60min preop; Max: 2000 mg/dose if <120 kg, 3000 mg/dose if at least 120 kg; Info: may repeat dose q4h intraop

endocarditis treatment

[native valve]

Dose: 100 mg/kg/day IV divided q8h x4-6wk; Max: 12 g/day; Info: duration varies w/ pathogen susceptibility; may give w/ gentamicin gram positive synergy x3-5 days; refer to AHA guidelines

[prosthetic valve]

Dose: 100 mg/kg/day IV divided q8h for at least 6wk; Max: 12 g/day; Info: give w/ gentamicin gram positive synergy x2wk and rifampin; refer to AHA guidelines

endocarditis prophylaxis, dental

[50 mg/kg/dose IM/IV x1]

Start: 30-60min before procedure; Info: see Infectious Disease: Endocarditis Prophylaxis, Pediatric table

bacterial arthritis, acute (off-label)

[100-150 mg/kg/day IV divided q8h]

Info: dose, duration varies by organism, infection severity

renal dosing

[<1 mo]

renal impairment: not defined

HD/PD: not defined

[1 mo and older]

eGFR 11-30: give usual divided dose x1, then give 25 mg/kg/dose q12h; eGFR <10: give usual divided dose x1, then give 25 mg/kg/dose q24h

HD: give usual divided dose x1, then give 25 mg/kg/dose q24h, on dialysis days admin. after dialysis; no supplement; PD: give usual divided dose x1, then give 25 mg/kg/dose q24h; supplement not defined

hepatic dosing

[not defined]