aztreonam

Adult Dosing .

Dosage forms:  INJ

infections, mod. severe bacterial

[1-2 g IM/IV q8-12h]

Max: 8 g/day; Info: dose, duration varies w/ infection type, severity; IV route recommended for doses >1 g

infections, severe bacterial

[2 g IV q6-8h]

Max: 8 g/day; Info: dose, duration varies w/ infection type, severity

UTI

[0.5-1 g IM/IV q8-12h]

Max: 8 g/day

infection prophylaxis, surgical

[2 g IV x1]

Start: w/in 60min preop; Info: may repeat dose q4h intraop

pneumonia

[hospital-acquired or ventilator-assoc.]

Dose: 2 g IV q8h x7 days; Info: may extend duration based on clinical response; refer to IDSA guidelines

[community-acquired]

Dose: 2 g IV q6-8h x7 days; Info: for inpatient tx; refer to IDSA guidelines

renal dosing

[adjust dose amount]

CrCl 10-30: give usual dose x1, then decr. usual dose by 50%; CrCl <10: give usual dose x1, then decr. usual dose by 75%

HD: give usual dose x1, then decr. usual dose by 75%, on dialysis days admin. after dialysis; consider 12.5% usual dose as supplement if next maint. dose not due right after dialysis; PD: give usual dose x1, then decr. usual dose by 75%; no supplement

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

infections, bacterial

[neonates <7 days old, <2000 g (off-label)]

Dose: 60 mg/kg/day IV divided q12h

[neonates <7 days old, >2000 g (off-label)]

Dose: 90 mg/kg/day IV divided q8h

[neonates 7 days old and older, <1200 g (off-label)]

Dose: 60 mg/kg/day IV divided q12h

[neonates 7 days old and older, 1200-2000 g (off-label)]

Dose: 90 mg/kg/day IV divided q8h

[neonates 7 days old and older, >2000 g (off-label)]

Dose: 120 mg/kg/day IV divided q6h

[1-8 mo (off-label)]

Dose: 90-120 mg/kg/day IV divided q6-8h; Max: 120 mg/kg/day; Info: dose, duration varies w/ infection type, severity

[9 mo and older]

Dose: 90-120 mg/kg/day IV divided q6-8h; Max: 120 mg/kg/day up to 8 g/day; Info: dose, duration varies w/ infection type, severity

infection prophylaxis, surgical

[1 yo and older]

Dose: 30 mg/kg/dose IV x1; Start: w/in 60min preop; Max: 2000 mg/dose; Info: may repeat dose q4h intraop

resp. infections, cystic fibrosis pts (off-label)

[200 mg/kg/day IV divided q6h]

Max: 8 g/day

renal dosing

[adjust dose amount, frequency]

CrCl 10-30: give usual divided dose x1, then give 50-75% usual divided dose q8h; CrCl <10: give usual divided dose x1, then give 25-33% usual divided dose q12h

HD: give usual divided dose x1, then give 25-33% usual divided dose q12h, on dialysis days admin. after dialysis; consider 12% usual divided dose as supplement if next maint. dose not due right after dialysis; PD: give usual divided dose x1, then give 25-33% usual divided dose q12h; no supplement

hepatic dosing

[no adjustment]