cefotetan

Adult Dosing .

Dosage forms:  INJ

infections, mild-mod. bacterial

[1-2 g IM/IV q12h]

Alt: 2 g IM/IV q24h; Max: 4 g/day; Info: dose, duration varies w/ infection type, severity

infections, severe-life threatening bacterial

[2-3 g IV q12h]

Max: 6 g/day; Info: dose, duration varies w/ infection type, severity

PID, severe

[2 g IV q12h x14 days]

Info: give w/ doxycycline; 1st-line agent; switch to PO regimen ASAP to complete course

intra-abdominal infections

[2-3 g IV q12h]

Max: 6 g/day; Info: dose, duration varies w/ infection severity

infection prophylaxis, surgical

[2 g IV x1]

Start: w/in 60min preop; Info: may repeat dose q6h intraop

renal dosing

[if usual frequency q12h]

CrCl 10-30: give usual dose q24h or decr. usual dose by 50%; CrCl <10: give usual dose q48h or decr. usual dose by 75%

HD: 1 g 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; Alt: give 50% usual dose after dialysis on dialysis days, give 25% usual dose on non-dialysis days; consider supplement if next maint. dose not due right after dialysis; PD: 1 g q24h; supplement not defined

[if usual frequency q24h]

renal impairment: consider decr. usual dose or frequency

HD: consider decr. usual dose or frequency; consider supplement if next maint. dose not due right after dialysis; PD: consider decr. usual dose or frequency; supplement not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

infections, bacterial (off-label)

[40-80 mg/kg/day IM/IV divided q12h]

Max: 4 g/day; 6 g/day for life-threatening infections; Info: dose, duration varies w/ infection type, severity

PID, severe (off-label)

[adolescents]

Dose: 2 g IV q12h x14 days; Info: give w/ doxycycline; 1st-line agent; switch to PO regimen ASAP to complete course

infection prophylaxis, surgical (off-label)

[1 yo and older]

Dose: 40 mg/kg/dose IV x1; Start: w/in 60min preop; Max: 2000 mg/dose; Info: may repeat dose q6h intraop

renal dosing

[see below]

CrCl 10-30: decr. usual divided dose by 50%; CrCl <10: decr. usual divided dose by 75%

HD: give 25% usual divided dose q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: give 50% usual divided dose q24h; supplement not defined

hepatic dosing

[not defined]