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Xphozah
tenapanor
Adult Dosing .
Dosage forms: TAB: 10 mg, 20 mg, 30 mg
hyperphosphatemia, dialysis pts
- [30 mg PO bid]
- Info: for pts w/ inadequate response or intolerance to phosphate binders; may adjust dose based on GI tolerability; give immediately before meals
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- pts <6 yo
- GI obstruction, known or suspected
Drug Interactions .
Overview
tenapanor
NHE3 inhibitor
- OATP2B1 inhibitor
- binds to cation exchange resin/polymer
- hypophosphatemia
Avoid/Use Alternative
- erdafitinib
Monitor/Modify Tx
- enalapril
- sodium polystyrene sulfonate
Caution Advised
- fexofenadine
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available, though risk of fetal harm not expected based on minimal systemic absorption; no known risk of teratogenicity based on animal data at up to 16.5x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on minimal maternal systemic absorption
Pharmacology .
Metabolism: unknown; CYP450: 3A4/5 substrate; Info: minimal systemic absorption
Excretion: feces 70-79% (65% unchanged), urine 9% (minimally unchanged); Half-life: unknown
Subclass: Hyperphosphatemia
Mechanism of Action
inhibits sodium/hydrogen exchanger 3 (NHE3), decreasing intestinal phosphate absorption
Formulary .
No Formulary Selected
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