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atenolol
generic
Black Box Warnings .
Avoid Abrupt Cessation
abrupt cessation in pts w/ CAD may cause angina exacerbation, MI, and ventricular arrhythmias; taper gradually and monitor when D/C chronic tx; restart tx if angina worsens or acute coronary insufficiency develops; avoid abrupt D/C in all pts in case unrecognized CAD
Adult Dosing .
Dosage forms: TAB: 25 mg, 50 mg, 100 mg
HTN
- [25-100 mg PO qd]
- Start: 25-50 mg PO qd, may incr. dose q1-2wk; Max: 100 mg/day; Info: taper dose gradually to D/C
angina
- [50-200 mg PO qd]
- Start: 50 mg PO qd, may incr. dose qwk; Max: 200 mg/day; Info: taper dose gradually to D/C
cardiovascular event risk reduction, post-MI
- [100 mg/day PO divided qd-bid]
- Info: start ASAP after pt stable; taper dose gradually to D/C
atrial fibrillation/flutter (off-label)
- [25-100 mg PO qd]
- Start: 25-50 mg PO qd; Max: 100 mg/day; Info: for maintenance rate control; taper dose gradually to D/C
migraine prophylaxis (off-label)
- [100 mg PO qd]
- Start: 50 mg PO qd, titrate slowly; Info: taper dose gradually to D/C
essential tremor (off-label)
- [50-150 mg PO qd]
- Start: 50 mg PO qd, titrate slowly; Max: 150mg/day; Info: taper dose gradually to D/C
renal dosing
- [adjust dose amount]
- CrCl 15-35: max 50 mg/day; CrCl <15: max 25 mg/day
- HD: 25 mg qd, on dialysis days admin. after dialysis; give 25-50 mg as supplement if next maint. dose not due right after dialysis; PD: 25 mg qd; no supplement
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: TAB: 25 mg, 50 mg, 100 mg
HTN (off-label)
- [1-2 mg/kg/dose PO qd]
- Start: 0.8-1 mg/kg/dose PO qd; Max: 2 mg/kg/day; Info: taper dose gradually to D/C
supraventricular arrhythmia (off-label)
- [0.3-2 mg/kg/dose PO qd]
- Max: 2 mg/kg/day; Info: optimal dose not well established; taper dose gradually to D/C
aortic dilation, Marfan syndrome-assoc. (off-label)
- [6 mo and older]
- Dose: 1-4 mg/kg/dose PO qd; Start: 0.5 mg/kg/dose PO qd; Max: 250 mg/day; Info: taper dose gradually to D/C
renal dosing
- [adjust dose amount, frequency]
- CrCl 15-35: 1 mg/kg/dose up to 50 mg q24h; CrCl <15: 1 mg/kg/dose up to 50 mg q48h
- HD: 1 mg/kg/dose up to 50 mg q48h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 1 mg/kg/dose up to 50 mg q48h; no supplement
hepatic dosing
- [not defined]