foscarnet

Adult Dosing .

Dosage forms:  INJ

CMV retinitis, AIDS-associated

[induction tx]

Dose: 90 mg/kg/dose IV q12h x2-3wk; Alt: 60 mg/kg/dose IV q8h x2-3wk; Info: not 1st-line tx; maintain adequate hydration prior to and during tx

[maintenance tx]

Dose: 90 mg/kg/dose IV q24h or 120 mg/kg/dose IV q24h; Info: not 1st-line tx; may consider dose incr. to 120 mg/kg/dose if reinduction needed for dz progression; maintain adequate hydration prior to and during tx

mucocutaneous HSV infection, acyclovir-resistant

[40 mg/kg/dose IV q8-12h until healed]

Alt: apply 1% crm 5x/day until healed, dose requires pharmacy compounding; Info: for immunocompromised pts; maintain adequate hydration prior to and during IV tx

CMV dz, ganciclovir-resistant (off-label)

[induction tx]

Dose: 90 mg/kg/dose IV q12h for at least 2wk; Alt: 60 mg/kg/dose IV q8h for at least 2wk; Info: for immunocompromised pts; maintain adequate hydration prior to and during tx; duration and need for maint. tx depends on infection site and severity, clinical response, virologic clearance

[maintenance tx]

Dose: 90 mg/kg/dose IV q24h or 120 mg/kg/dose IV q24h; Info: for immunocompromised pts; may consider dose incr. to 120 mg/kg/dose if reinduction needed for dz progression; maintain adequate hydration prior to and during tx; duration depends on infection site and severity, clinical response, virologic clearance

varicella (chickenpox), acyclovir-resistant (off-label)

[90 mg/kg/dose IV q12h]

Info: for immunocompromised pts; maintain adequate hydration prior to and during tx

herpes zoster (shingles), acyclovir-resistant (off-label)

[90 mg/kg/dose IV q12h]

Info: for immunocompromised pts; maintain adequate hydration prior to and during tx

renal dosing

[CMV induction tx]

Info: CrCl expressed as mL/min/kg; CrCl 1-1.4: 70 mg/kg/dose q12h or 45 mg/kg/dose q8h; CrCl 0.8-1: 50 mg/kg/dose q12h; CrCl 0.6-0.8: 80 mg/kg/dose q24h or 40 mg/kg/dose q12h; CrCl 0.5-0.6: 60 mg/kg/dose q24h; CrCl 0.4-0.5: 50 mg/kg/dose q24h; CrCl <0.4: avoid use

HD: 45-50 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 60 mg/kg/dose q48-72h; supplement not defined

[CMV maintenance tx]

Info: CrCl expressed as mL/min/kg; CrCl 1-1.4: 70 mg/kg/dose q24h or 90 mg/kg/dose q24h; CrCl 0.8-1: 50 mg/kg/dose q24h or 65 mg/kg/dose q24h; CrCl 0.6-0.8: 80 mg/kg/dose q48h or 105 mg/kg/dose q48h; CrCl 0.5-0.6: 60 mg/kg/dose q48h or 80 mg/kg/dose q48h; CrCl 0.4-0.5: 50 mg/kg/dose q48h or 65 mg/kg/dose q48h; CrCl <0.4: avoid use

HD: 45-50 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 60 mg/kg/dose q48-72h; supplement not defined

[HSV infection]

Info: CrCl expressed as mL/min/kg; CrCl 1-1.4: 30 mg/kg/dose q8-12h; CrCl 0.8-1: 20 mg/kg/dose q12h or 35 mg/kg/dose q12h; CrCl 0.6-0.8: 35 mg/kg/dose q24h or 25 mg/kg/dose q12h; CrCl 0.5-0.6: 25 mg/kg/dose q24h or 40 mg/kg/dose q24h; CrCl 0.4-0.5: 20 mg/kg/dose q24h or 35 mg/kg/dose q24h; CrCl <0.4: avoid use

HD: 45-50 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 60 mg/kg/dose q48-72h; supplement not defined

[all other indications]

Info: CrCl expressed as mL/min/kg; CrCl 1-1.4: 70 mg/kg/dose q12h; CrCl 0.8-1: 50 mg/kg/dose q12h; CrCl 0.6-0.8: 80 mg/kg/dose q24h; CrCl 0.5-0.6: 60 mg/kg/dose q24h; CrCl 0.4-0.5: 50 mg/kg/dose q24h; CrCl <0.4: avoid use

HD: 45-50 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 60 mg/kg/dose q48-72h; supplement not defined

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.