Humate-P

Adult Dosing .

Dosage forms:  INJ

von Willebrand dz

[bleeding episode, minor]

Dose: 30-60 units/kg/dose IV x1, then 20-40 units/kg/dose IV q12-48h; Info: individualize dose to maintain trough VWF:RCo and factor VIII levels >50% x3-5 days; dose, duration varies by site/severity of bleeding, severity of dz

[bleeding episode, major]

Dose: 40-60 units/kg/dose IV x1, then 20-40 units/kg/dose IV q8-24h; Info: individualize dose to maintain trough VWF:RCo and factor VIII levels >50% x7-14 days; dose, duration varies by site/severity of bleeding, severity of dz

[bleeding prophylaxis, minor surgery]

Dose: 30-60 units/kg/dose IV x1 preop, then 20-40 units/kg/dose IV q12-48h; Start: 1-2h before surgery; Info: individualize dose to maintain trough VWF:RCo and factor VIII levels >50% x3-5 days; dose, duration varies by site/severity of bleeding, severity of dz

[bleeding prophylaxis, major surgery]

Dose: 40-60 units/kg/dose IV x1 preop, then 20-40 units/kg/dose IV q8-24h; Start: 1-2h before surgery; Info: individualize dose to maintain trough VWF:RCo and factor VIII levels >50% x7-14 days; dose, duration varies by site/severity of bleeding, severity of dz

hemophilia A

[bleeding episode, minor]

Dose: individualize dose IV x1; may repeat dose q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 20-40%; 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, moderate]

Dose: individualize dose IV q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%; 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

[bleeding episode, major]

Dose: individualize dose IV q8-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 80-100%; 1 unit/kg will incr. factor VIII level approx. 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

von Willebrand dz

[bleeding episode, minor]

Dose: 30-60 units/kg/dose IV x1, then 20-40 units/kg/dose IV q12-48h; Info: individualize dose to maintain trough VWF:RCo and factor VIII levels >50% x3-5 days; dose, duration varies by site/severity of bleeding, severity of dz

[bleeding episode, major]

Dose: 40-60 units/kg/dose IV x1, then 20-40 units/kg/dose IV q8-24h; Info: individualize dose to maintain trough VWF:RCo and factor VIII levels >50% x7-14 days; dose, duration varies by site/severity of bleeding, severity of dz

[bleeding prophylaxis, minor surgery]

Dose: 30-60 units/kg/dose IV x1 preop, then 20-40 units/kg/dose IV q12-48h; Start: 1-2h before surgery; Info: individualize dose to maintain trough VWF:RCo and factor VIII levels >50% x3-5 days; dose, duration varies by site/severity of bleeding, severity of dz

[bleeding prophylaxis, major surgery]

Dose: 40-60 units/kg/dose IV x1 preop, then 20-40 units/kg/dose IV q8-24h; Start: 1-2h before surgery; Info: individualize dose to maintain trough VWF:RCo and factor VIII levels >50% x7-14 days; dose, duration varies by site/severity of bleeding, severity of dz

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]