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Levophed
norepinephrine
Black Box Warnings .
Extravasation
to prevent sloughing/necrosis in peripheral ischemic areas promptly use syringe w/ fine hypodermic needle to liberally infiltrate area w/ 10-15 mL saline solution containing 5-10 mg phentolamine; sympathetic blockade causes immediate conspicuous local hyperemic changes if area infiltrated w/in 12h
Adult Dosing .
Dosage forms: INJ
hypotension, acute
- [weight-based dosing]
- Dose: 0.02-1 mcg/kg/min IV; Start: 0.1-0.5 mcg/kg/min IV, then titrate to effect; Info: pts w/ septic shock may require higher doses
- [non weight-based dosing]
- Dose: 2-4 mcg/min IV; Start: 8-12 mcg/min IV, then titrate to effect; Info: pts w/ septic shock may require higher doses
cardiac arrest, adjunct tx
- [weight-based dosing]
- Dose: 0.02-1 mcg/kg/min IV; Start: 0.1-0.5 mcg/kg/min IV, then titrate to effect; Info: for post-resuscitation stabilization
- [non weight-based dosing]
- Dose: 2-4 mcg/min IV; Start: 8-12 mcg/min IV, then titrate to effect; Info: for post-resuscitation stabilization
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
hypotension, acute (off-label)
- [2-12 yo]
- Dose: 0.1-2 mcg/kg/min IV; Start: 0.05-0.1 mcg/kg/min IV, then titrate to effect; Max: 2 mcg/kg/min
post-resuscitation stabilization (off-label)
- [0.1-2 mcg/kg/min IV]
- Start: 0.05-0.1 mcg/kg/min IV, then titrate to effect; Max: 2 mcg/kg/min; Info: refer to PALS guidelines
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [not defined]