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desipramine
generic
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds use
Adult Dosing .
Dosage forms: TAB: 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg
depression
- [100-200 mg PO qd]
- Start: 25-75 mg PO qd; Max: 300 mg/day; Info: in elderly pts start 25 mg PO qd, max 150 mg/day; may give in divided doses; taper dose gradually to D/C
rapid eye movement sleep behavior disorder (off-label)
- [50 mg PO qhs]
- Info: taper dose gradually to D/C
IBS (off-label)
- [25-100 mg PO qd]
- Start: 10 mg PO qd, titrate slowly; Max: 100 mg/day; Info: taper dose gradually to D/C
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: TAB: 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg
depression
- [13 yo and older]
- Dose: 25-100 mg PO qd; Start: 25 mg PO qd; Max: 150 mg/day; Info: may give in divided doses; taper dose gradually to D/C
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised