Select a medication above to begin.
ceftriaxone
generic
Adult Dosing .
Dosage forms: INJ
infections, bacterial
- [1-2 g IM/IV q24h]
- Info: dose, duration varies w/ infection type, severity
meningitis, bacterial
- [2 g IV q12h x7-21 days]
pneumonia, community-acquired
- [1-2 g IM/IV q24h for at least 5 days]
- Info: for inpatient tx; refer to IDSA guidelines
infections, uncomplicated gonococcal
- [treatment]
- Dose: 500 mg IM x1; Info: for pts <150 kg; give 1 g IM x1 if wt >150 kg; 1st-line agent; if chlamydial infection not excluded, give w/ doxycycline, or azithromycin in pregnant pts
- [presumptive tx (off-label)]
- Dose: 500 mg IM x1; Info: for sexual assault victims <150 kg; give 1 g IM x1 if wt >150 kg; give w/ doxycycline and metronidazole in female pts; give w/ doxycycline in male pts
infections, disseminated gonococcal
- [arthritis or arthritis-dermatitis]
- Dose: 1 g IM/IV q24h for at least 7 days; Info: may switch to PO regimen to complete course after 24-48h of clinical improvement; 1st-line agent; if chlamydial infection not excluded, give w/ doxycycline, or azithromycin in pregnant pts
- [meningitis]
- Dose: 1-2 g IV q12-24h x10-14 days; Info: if chlamydial infection not excluded, give w/ doxycycline, or azithromycin in pregnant pts
- [endocarditis]
- Dose: 1-2 g IV q12-24h for at least 4wk; Info: if chlamydial infection not excluded, give w/ doxycycline, or azithromycin in pregnant pts
conjunctivitis, gonococcal
- [1 g IM x1]
- Info: consider giving w/ saline lavage x1
PID
- [mild-moderate infection]
- Dose: 500 mg IM x1; Info: for pts <150 kg; give 1 g IM x1 if wt >150 kg; give w/ doxycycline and metronidazole; 1st-line agent
- [severe infection]
- Dose: 1 g IV q24h; Info: give w/ doxycycline and metronidazole; 1st-line agent; switch to PO regimen ASAP to complete course
UTI
- [1 g IV x1]
- Info: for pyelonephritis; to complete tx, give ciprofloxacin, levofloxacin, or sulfamethoxazole/trimethoprim; refer to IDSA guidelines
endocarditis treatment (off-label)
- [2g IV/IM q12-24h x4-6wk]
- Info: dose, frequency, duration vary w/ pathogen susceptibility, infection severity, valve type; refer to AHA guidelines
endocarditis prophylaxis, dental (off-label)
- [1 g IM/IV x1]
- Start: 30-60min before procedure; Info: see Infectious Disease: Endocarditis Prophylaxis, Adult table
proctitis (off-label)
- [500 mg IM x1]
- Info: for pts <150 kg; give 1 g IM x1 if wt >150 kg; give w/ doxycycline
epididymitis (off-label)
- [500 mg IM x1]
- Info: for pts <150 kg; give 1 g IM x1 if wt >150 kg; give w/ doxycycline if only chlamydia or gonorrhea suspected; give w/ levofloxacin if chlamydia, gonorrhea, or enteric organisms suspected
chancroid (off-label)
- [250 mg IM x1]
salmonellosis, acute (off-label)
- [2 g IV q24h x3-7 days]
- Info: for pts at risk for invasive dz; may extend tx if immunocompromised
shigellosis, severe (off-label)
- [1-2 g IM/IV q24h]
- Info: duration varies w/ infection severity; refer to CDC guidance
non-cholera vibrio infection, invasive dz (off-label)
- [2 g IV q12h x10-14 days]
- Info: part of multi-drug regimen; may extend tx if immunocompromised
typhoid fever (off-label)
- [60 mg/kg/dose IV q24h x2wk]
- Max: 4 g/24h
Lyme dz (off-label)
- [2 g IV q24h x14-21 days]
- Info: may consider extending duration to 28 days if Lyme arthritis; may switch to PO regimen when possible to complete course; 1st-line agent; search 'Lyme' for epocrates Lyme Disease Dx & Tx decision tool
neurosyphilis (off-label)
- [1-2 g IM/IV q24h x10-14 days]
- Info: for nonpregnant pts w/ hypersens. to PCN; not 1st-line agent
meningococcal prophylaxis (off-label)
- [250 mg IM x1]
- Info: for close contacts of pts w/ invasive meningococcal dz
renal dosing
- [see below]
- renal failure: no adjustment; Info: max maint. dose 2 g/day if also hepatic impairment
- HD/PD: no adjustment; no supplement; Info: max maint. dose 2 g/day if also hepatic impairment
hepatic dosing
- [see below]
- hepatic impairment: not adjustment; Info: max 2 g/day if also significant renal dz
Peds Dosing .
- Dosage forms: INJ
infections, bacterial
- [neonates, 0-7 days old]
- Dose: 50 mg/kg/dose IM/IV q24h; Info: duration varies w/ infection type, severity
- [neonates, >7 days old, <2000 g]
- Dose: 50 mg/kg/dose IM/IV q24h; Info: duration varies w/ infection type, severity
- [neonates, >7 days old, >2000 g]
- Dose: 50-75 mg/kg/dose IM/IV q24h; Info: dose, duration vary w/ infection type, severity
- [infants/children]
- Dose: 50-100 mg/kg/day IM/IV divided q12-24h; Max: 4 g/24h; Info: dose, duration vary w/ infection type, severity
meningitis, bacterial
- [infants/children]
- Dose: 80-100 mg/kg/day IV divided q12-24h x7-21 days; Start: 100 mg/kg/dose IV x1; Max: 4 g/24h
otitis media, acute
- [6 mo-12 yo]
- Dose: 50 mg/kg/dose IM/IV q24h x1-3 days; Max: 1 g/dose; Info: duration varies w/ infection severity
community-acquired pneumonia
- [>3 mo]
- Dose: 50-100 mg/kg/day IM/IV divided q12-24h x10 days; Max: 2 g/day; Info: may switch to PO regimen when possible to complete course
infections, uncomplicated gonococcal (off-label)
- [treatment, children <45 kg]
- Dose: 25-50 mg/kg/dose IM/IV x1; Max: 250 mg/dose
- [treatment, children >45 kg and adolescents]
- Dose: 500 mg IM x1; Info: for pts <150 kg; give 1 g IM x1 if wt >150 kg; 1st-line agent; if chlamydial infection not excluded, give w/ doxycycline, or azithromycin in pregnant pts
- [presumptive tx, neonates]
- Dose: 25-50 mg/kg/dose IM/IV x1; Max: 250 mg/dose; Info: for neonates born to mothers w/ untreated gonococcal infection
- [presumptive tx, adolescents]
- Dose: 500 mg IM x1; Info: for sexual assault victims <150 kg; give 1 g IM x1 if wt >150 kg; give w/ doxycycline and metronidazole in female pts; give w/ doxycycline in male pts
infections, disseminated gonococcal (off-label)
- [neonates]
- Dose: 25-50 mg/kg/dose IM/IV q24h x7 days; Info: extend duration to 10-14 days if meningitis
- [children <45 kg]
- Dose: 50 mg/kg/dose IM/IV q24h x7 days; Max: 2 g/dose; Info: for bacteremia or arthritis
- [children >45 kg]
- Dose: 1 g IM/IV q24h x7 days; Info: for bacteremia or arthritis
- [adolescents]
- see Adult Dosing
ophthalmia neonatorum, gonococcal (off-label)
- [25-50 mg/kg/dose IM/IV x1]
- Max: 250 mg/dose
conjunctivitis, gonococcal (off-label)
- [adolescents]
- Dose: 1 g IM x1; consider giving w/ saline lavage x1
endocarditis treatment (off-label)
- [100 mg/kg/day IV divided q12h for at least 4wk]
- Max: 4 g/day; Alt: 80 mg/kg/dose IV q24h for at least 4wk; Info: duration varies w/ pathogen susceptibility, valve type; refer to AHA guidelines
endocarditis prophylaxis, dental (off-label)
- [50 mg/kg/dose IM/IV x1]
- Start: 30-60min before procedure; Info: see Infectious Disease: Endocarditis Prophylaxis, Pediatric table
ophthalmia neonatorum (off-label)
- [25-50 mg/kg/dose IM/IV x1]
- Max: 125 mg/dose
PID (off-label)
- [mild-moderate infection, preadolescents >45 kg and adolescents]
- Dose: 500 mg IM x1; Info: for pts <150 kg; give 1 g IM x1 if wt >150 kg; give w/ doxycycline and metronidazole; 1st-line agent
- [severe infection, preadolescents >45 kg and adolescents]
- Dose: 1 g IV q24h; Info: give w/ doxycycline and metronidazole; 1st-line agent; switch to PO regimen ASAP to complete course
proctitis (off-label)
- [preadolescents >45 kg and adolescents]
- Dose: 500 mg IM x1; Info: for pts <150 kg; give 1 g IM x1 if wt >150 kg; give w/ doxycycline
epididymitis (off-label)
- [preadolescents >45 kg and adolescents]
- Dose: 500 mg IM x1; Info: for pts <150 kg; give 1 g IM x1 if wt >150 kg; give w/ doxycycline if only chlamydia or gonorrhea suspected; give w/ levofloxacin if chlamydia, gonorrhea, or enteric organisms suspected
chancroid (off-label)
- [preadolescents <45 kg]
- Dose: 50 mg/kg/dose IM x1; Max: 250 mg/dose
- [preadolescents >45 kg and adolescents]
- Dose: 250 mg IM x1
salmonellosis, acute (off-label)
- [1 mo-12 yo]
- Dose: 50-100 mg/kg/day IM/IV divided q12-24h x3-7 days; Max: 2 g/day; Info: for pts at risk for invasive dz; may extend tx if immunocompromised
- [13 yo and older]
- Dose: 2 g IV q24h x3-7days; Max: 2 g/day; Info: for pts at risk for invasive dz; may extend tx if immunocompromised
shigellosis, severe (off-label)
- [1 mo-12 yo]
- Dose: 50-100 mg/kg/day IM/IV divided q12-24h; Max: 2 g/day; Info: duration varies w/ infection severity; refer to CDC guidance
- [13 yo and older]
- Dose: 1-2 g IM/IV q24h; Max: 2 g/day; Info: duration varies w/ infection severity; refer to CDC guidance
non-cholera vibrio infection, invasive dz (off-label)
- [1 mo-12 yo]
- Dose: 50-100 mg/kg/day IM/IV divided q12-24h x10-14 days; Max: 2 g/day; Info: part of multi-drug regimen; may extend tx if immunocompromised
- [13 yo and older]
- Dose: 2 g IV q12h x10-14 days; Info: part of multi-drug regimen; may extend tx if immunocompromised
typhoid fever (off-label)
- [100 mg/kg/dose IV q24h x10-14 days]
- Max: 4 g/24h
Lyme dz (off-label)
- [50-75 mg/kg/dose IV q24h x14-21 days]
- Max: 2 g/day; Info: may consider extending duration to 28 days if Lyme arthritis; may switch to PO regimen when possible to complete course; 1st-line agent; search 'Lyme' for epocrates Lyme Disease Dx & Tx decision tool
syphilis, congenital (off-label)
- [neonates]
- Dose: 50-75 mg/kg/dose IV q24h x10-14 days; Info: not 1st-line agent
- [infants]
- Dose: 75 mg/kg/dose IM/IV q24h x10-14 days; Info: not 1st-line agent
- [children]
- Dose: 100 mg/kg/dose IM/IV q24h x10-14 days; Info: not 1st-line agent
neurosyphilis (off-label)
- [adolescents]
- Dose: 1-2 g IM/IV q24h x10-14 days]; Info: for nonpregnant pts w/ hypersens. to PCN; not 1st-line agent
meningococcal prophylaxis (off-label)
- [<15 yo]
- Dose: 125 mg IM x1; Info: for close contacts of pts w/ invasive meningococcal dz
- [15 yo and older]
- Dose: 250 mg IM x1; Info: for close contacts of pts w/ invasive meningococcal dz
renal dosing
- [adjust dose frequency]
- CrCl <10: give usual dose q24h
- HD: give usual dose q24h; no supplement after dialysis; PD: give usual dose q24h; no supplement
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance