captopril

Adult Dosing .

Dosage forms:  TAB: 12.5 mg, 25 mg, 50 mg, 100 mg

HTN

[12.5-150 mg/day PO divided bid-tid]

Start: 25 mg PO bid-tid, may incr. to 50 mg PO bid-tid after 1-2wk; Info: decr. start dose if also on diuretic; give 1h before meals; may titrate dose q24h or more frequently under direct supervision if severe HTN

heart failure w/ reduced ejection fraction

[50 mg PO tid]

Start: 6.25 mg PO tid, may incr. dose q1-2wk; Info: give 1h before meals

left ventricular dysfxn, post-MI

[50 mg PO tid]

Start: 6.25 mg PO x1 w/in 24h post-MI, then 12.5 mg PO tid, then incr. over several days to 25 mg PO tid, then incr. over several wk to 50 mg PO tid as tolerated; Info: give 1h before meals

nephropathy, diabetic

[25 mg PO tid]

Info: give 1h before meals

renal dosing

[adjust dose amount, frequency]

CrCl 10-50: give 75% usual dose q12-18h; CrCl <10: give 50% usual dose q24h

HD: give 50% usual dose q24h, on dialysis days admin. after dialysis; no supplement; PD: give 75% usual dose q12-18h; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 12.5 mg, 25 mg, 50 mg, 100 mg

HTN (off-label)

[premature neonates]

Dose: 0.1-0.4 mg/kg/day PO divided q6-24h; Start: 0.01 mg/kg/dose; Max: 2 mg/kg/day; Info: give 1h before meals

[neonates]

Dose: 0.1-0.4 mg/kg/day PO divided q6-24h; Start: 0.05-0.1 mg/kg/dose; Max: 2 mg/kg/day; Info: give 1h before meals

[infants]

Dose: 2.5-6 mg/kg/day PO divided q6-24h; Start: 0.05 mg/kg/dose; Max: 6 mg/kg/day; Info: give 1h before meals

[children]

Dose: 2.5-6 mg/kg/day PO divided q8h; Start: 0.5 mg/kg/dose; Max: 6 mg/kg/day; Info: give 1h before meals

[adolescents]

Dose: 25-50 mg PO q6-8h; Start: 12.5-25 mg PO q8h, incr. 12.5-25 mg/dose q1-2wk; Max: 450 mg/day; Info: use lower initial dose if on diuretics; give 1h before meals

heart failure w/ reduced ejection fraction (off-label)

[premature neonates]

Dose: 0.1-0.4 mg/kg/day PO divided q6-24h; Start: 0.01 mg/kg/dose; Max: 2 mg/kg/day; Info: give 1h before meals

[neonates]

Dose: 0.1-0.4 mg/kg/day PO divided q6-24h; Start: 0.05-0.1 mg/kg/dose; Max: 2 mg/kg/day; Info: give 1h before meals

[infants]

Dose: 2.5-6 mg/kg/day PO divided q6-12h; Start: 0.15-0.3 mg/kg/dose; Max: 6 mg/kg/day; Info: give 1h before meals

[children]

Dose: 2.5-6 mg/kg/day PO divided q6-12h; Start: 0.3-0.5 mg/kg/dose or 6.25-12.5 mg/dose; Max: 6 mg/kg/day; Info: give 1h before meals

[adolescents]

Dose: 25-50 mg PO q6-8h; Start: 12.5-25 mg PO q8h, incr. 12.5-25 mg/dose q1-2wk; Max: 450 mg/day; Info: use lower initial dose if on diuretics; give 1h before meals

renal dosing

[adjust dose amount]

CrCl 10-50: decr. usual dose by 25%; CrCl <10: decr. usual dose by 50%

HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement

hepatic dosing

[not defined]