Zosyn

Adult Dosing .

Dosage forms:  INJ

Special Note

[strength clarification]

Info: doses expressed as total piperacillin + tazobactam amt; 3.375 g piperacillin/tazobactam contains 3 g piperacillin + 0.375 g tazobactam; 4.5 g piperacillin/tazobactam contains 4 g piperacillin + 0.5 g tazobactam

intra-abdominal infections

[3.375 g IV q6h x4-7 days]

Info: for appendicitis or peritonitis

gynecologic infections

[3.375 g IV q6h x7-10 days]

Info: for postpartum endometritis or PID

skin/skin structure infections

[3.375 g IV q6h x7-10 days]

pneumonia

[hospital-acquired or ventilator-assoc.]

Dose: 4.5 g IV q6h x7 days; Info: may extend duration based on clinical response; refer to IDSA guidelines

[community-acquired]

Dose: 4.5 g IV q6h x7 days; Info: for inpatient tx; refer to IDSA guidelines

febrile neutropenia, chemo-induced (off-label)

[4.5 g IV q6h]

Info: for empiric tx in high-risk pts

renal dosing

[if usual dose 3.375 g q6h]

CrCl 20-40: 2.25 g q6h; CrCl <20: 2.25 g q8h

HD: 2.25 g q12h; give 0.75 g as supplement after dialysis if next maint. dose not due right after dialysis; PD: 2.25 g q12h; no supplement

[if usual dose 4.5 g q6h]

CrCl 20-40: 3.375 g q6h; CrCl <20: 2.25 g q6h

HD: 2.25 g q8h; give 0.75 g as supplement after dialysis if next maint. dose not due right after dialysis; PD: 2.25 g q8h; no supplement

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

Special Note

[strength clarification]

Info: doses expressed as total piperacillin + tazobactam amt; 3.375 g piperacillin/tazobactam contains 3 g piperacillin + 0.375 g tazobactam; 4.5 g piperacillin/tazobactam contains 4 g piperacillin + 0.5 g tazobactam

intra-abdominal infections

[2-9 mo]

Dose: 270 mg/kg/day IV divided q8h x4-7 days; Info: for appendicitis or peritonitis

[9 mo and older, <40 kg]

Dose: 337.5 mg/kg/day IV divided q8h x4-7 days; Info: for appendicitis or peritonitis

[9 mo and older, >40 kg]

Dose: 3.375 g IV q6h x4-7 days; Info: for appendicitis or peritonitis

nosocomial pneumonia

[2-9 mo]

Dose: 360 mg/kg/day IV divided q6h x7-14 days

[9 mo and older, <40 kg]

Dose: 450 mg/kg/day IV divided q6h x7-14 days

[9 mo and older, >40 kg]

Dose: 4.5 g IV q6h x7-14 days

febrile neutropenia, chemo-induced (off-label)

[2-9 mo]

Dose: 270 mg/kg/day IV divided q8h; Info: for empiric tx in high-risk pts

[9 mo and older, <40 kg]

Dose: 337.5 mg/kg/day IV divided q8h; Info: for empiric tx in high-risk pts

[9 mo and older, >40 kg]

Dose: 3.375 g IV q6h; Info: for empiric tx in high-risk pts

renal dosing

[see below]

CrCl 30-50: give 50-75% usual divided dose q6-8h; CrCl <30: give 50-75% usual divided dose q8h

HD: give 50-75% usual divided dose q12h; give 25% usual divided dose as supplement after dialysis if next maint. dose not due right after dialysis; PD: give 50-75% usual divided dose q12h; no supplement

hepatic dosing

[no adjustment]