carbidopa/ levodopa

Adult Dosing .

Dosage forms:  TAB: 10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg; ER TAB: 25 mg/100 mg, 50 mg/200 mg; ODT: 10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg

Special Note

[formulation clarification]

Info: carbidopa/levodopa ER tab not interchangeable w/ ER cap; do not substitute on a mg to mg basis

parkinsonism

[immediate-release form]

Dose: individualize dose PO tid-qid; Start: 10 mg/100 mg PO tid-qid or 25 mg/100 mg PO tid, may incr. by 1 tab/day q1-2 days; Max: 200 mg/2000 mg/day; Info: 70-100 mg/day carbidopa needed to saturate periph. dopa decarboxylase and minimize adverse effects; taper dose gradually to D/C

[extended-release form]

Dose: individualize dose ER PO bid-tid; Start: 50 mg/200 mg ER PO bid, separate doses by >6h; may incr. by 0.5-1 tab/day q3 days; Max: 600 mg/2400 mg/day ER; Info: start 10% higher levodopa dose if switching from reg. release product; give maint. bid-tid doses q4-8h while awake; ER tab may be split, but do not crush/chew; taper dose gradually to D/C

sleep-related eating disorder (off-label)

[25 mg/100 mg PO qhs]

restless legs syndrome (off-label)

[immediate-release form]

Dose: 25 mg/100 mg PO qhs prn; Max: 50 mg/200 mg/day; Info: for intermittent sx; may start 12.5 mg/50 mg PO qhs x1-2 days; taper dose gradually to D/C

[extended-release form]

Dose: 25 mg/100 mg ER PO qhs prn; Max: 50 mg/200 mg/day ER; Info: for intermittent sx; ER tab may be split, but do not crush/chew; taper dose gradually to D/C

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 10 mg/100 mg, 25 mg/100 mg, 25 mg/250 mg

dystonia, generalized (off-label)

[2 yo and older]

Dose: individualize dose PO bid-tid; Start: 12.5 mg/50 mg PO bid, may incr. by 0.5-1 tab/day q3 days; Max: 20 mg/kg/day levodopa; Info: taper dose gradually to D/C

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]