levocarnitine

Adult Dosing .

Dosage forms:  TAB: 330 mg; SOL: 100 mg per mL

carnitine deficiency

[primary]

Dose: 990 mg PO bid-tid; Start: 330 mg PO tid, incr. gradually; Alt: start 1 g/day solution PO divided q3-4h, then may incr. gradually to 1-3 g/day PO divided q3-4h; Info: give oral solution slowly w/ or after meals if GI intolerance

[secondary]

Dose: 990 mg PO bid-tid; Start: 330 mg PO tid, incr. gradually; Alt: start 1 g/day solution PO divided q3-4h, then may incr. gradually to 1-3 g/day PO divided q3-4h; Info: give oral solution slowly w/ or after meals if GI intolerance

renal dosing

[see below]

renal impairment: no adjustment; Info: caution advised if severe impairment w/ high-dose use

HD/PD: not defined, caution advised w/ high-dose use

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 330 mg; SOL: 100 mg per mL

carnitine deficiency

[primary]

Dose: 50-100 mg/kg/day PO in divided doses; Start: 50 mg/kg/day, incr. gradually; Max: 3 g/day; Info: divide dose q8-12h if using tablets, q3-4h if using solution; give oral solution slowly w/ or after meals if GI intolerance

[secondary]

Dose: 50-100 mg/kg/day PO in divided doses; Start: 50 mg/kg/day, incr. gradually; Max: 3 g/day; Info: divide dose q8-12h if using tablets, q3-4h if using solution; give oral solution slowly w/ or after meals if GI intolerance

cyclic vomiting syndrome prophylaxis, adjunct tx (off-label)

[2 yo and older]

Dose: 50-100 mg/kg/day PO in divided doses; Max: 3 g/day; Info: divide dose q8-12h if using tablets, q3-4h if using solution; give oral solution slowly w/ or after meals if GI intolerance

renal dosing

[see below]

renal impairment: no adjustment; Info: caution advised if severe impairment w/ high-dose use

HD/PD: not defined, caution advised w/ high-dose use

hepatic dosing

[not defined]