Imitrex

Adult Dosing .

Dosage forms:  TAB: 25 mg, 50 mg, 100 mg; INJ (STATdose cartridge): 4 mg per 0.5 mL, 6 mg per 0.5 mL; INJ (STATdose pen): 4 mg per injection, 6 mg per injection

Dosage Forms Discontinued in US

[6 mg per 0.5 mL injectable vial form not avail. as brand; see generic]

migraine, acute

[PO route]

Dose: 25-100 mg PO x1; Max: 200 mg/24h; Info: may repeat dose x1 after at least 2h; may give up to 100 mg/24h PO if following initial inj. dose

[SC route]

Dose: 6 mg SC x1; Max: 6 mg/dose up to 12 mg/24h; Info: may repeat dose x1 after at least 1h; may decr. dose to 1-5 mg SC x1 if not tolerated

cluster headache, acute

[6 mg SC x1]

Max: 6 mg/dose up to 12 mg/24h; Info: may repeat dose x1 after at least 1h

cyclic vomiting syndrome, acute (off-label)

[6 mg SC x1]

Start: during prodrome or w/in 30-45min of vomiting onset; Max: 12 mg/24h, 6 doses/wk; Info: may repeat dose x1 after 2h

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[PO route]

mild-moderate impairment: max 50 mg/dose PO; severe impairment: contraindicated

[SC route]

severe impairment: contraindicated

Peds Dosing .

Dosage forms:  INJ (STATdose cartridge): 4 mg per 0.5 mL, 6 mg per 0.5 mL; INJ (STATdose pen): 4 mg per injection, 6 mg per injection

Dosage Forms Discontinued in US

[6 mg per 0.5 mL injectable vial form not avail. as brand; see generic]

migraine, acute (off-label)

[6 yo and older]

Dose: 3-6 mg SC x1; Max: 6 mg/dose up to 12 mg/24h; Info: may repeat dose x1 after at least 1h

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance