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nalbuphine
generic
Black Box Warnings .
Appropriate Use
should only be admin. as anesthesia adjunct by healthcare professionals trained in use of IV anesthetics and management of resp. effects of potent opioids; ensure opioid antagonist, resuscitative and intubation equipment, and oxygen readily available; reserve opioid analgesics for pts w/ inadequate tx alternatives; proper dosing and titration essential to decr. resp. depression risk
Respiratory Depression
serious, life-threatening, or fatal cases may occur even w/ recommended use, esp. during tx start or after dose incr; to decr. risk, initiate and titrate dose appropriately
Risks from Concomitant Use w/ Benzodiazepines, CNS Depressants
concomitant opioid use w/ benzodiazepines or other CNS depressants, incl. alcohol, may result in profound sedation, resp. depression, coma, and death; reserve concomitant use for pts w/ inadequate alternative tx options
Adult Dosing .
Dosage forms: INJ: 10 mg per mL, 20 mg per mL
pain, mod-severe
- [10 mg IV/IM/SC q3-6h prn]
- Max: 20 mg/dose up to 160 mg/day; Info: use lowest effective dose, shortest effective tx duration; taper dose by 25-50% q2-4 days to D/C if prolonged or long-term use
anesthesia adjunct
- [0.25-0.5 mg/kg/dose IV x1 prn]
- Start: 0.3-3 mg/kg/dose IV x1
pruritus, opioid-induced (off-label)
- [2-5 mg IV x1]
renal dosing
- [adjust dose amount]
- renal impairment: decr. usual dose, amount not defined
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- hepatic impairment: decr. usual dose, amount not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.