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dihydroergotamine
generic
Black Box Warnings .
Peripheral Ischemia w/ Concomitant Strong CYP3A4 Inhibitor Use
serious and/or life-threatening peripheral ischemia possible when given in combo w/ strong CYP3A4 inhibitors incl. protease inhibitors and macrolide antibiotics; CYP3A4 inhibition incr. serum levels and risk for vasospasm leading to cerebral ischemia and/or ischemia of extremities; concomitant use w/ strong CYP3A4 inhibitors contraindicated
Adult Dosing .
Dosage forms: INJ: 1 mg per mL
migraine, acute
- [1 mg SC/IM/IV x1]
- Max: 3 mg/24h SC/IM up to 6 mg/wk; 2 mg/24h IV up to 6 mg/wk; Info: may repeat dose q1h
cluster headache, acute
- [1 mg SC/IM/IV x1]
- Max: 3 mg/24h SC/IM up to 6 mg/wk; 2 mg/24h IV up to 6 mg/wk; Info: may repeat dose q1h
renal dosing
- [see below]
- mild-moderate impairment: not defined; severe impairment: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- severe impairment: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.