chloroquine phosphate

Adult Dosing .

Dosage forms:  TAB: 250 mg, 500 mg

Special Note

[strength clarification]

Info: 500 mg chloroquine phosphate = 300 mg chloroquine base; doses expressed as chloroquine phosphate

malaria prophylaxis

[500 mg PO qwk]

Start: 1-2wk before exposure; if starting after exposure, give 500 mg PO q6h x2 doses, then 500 mg PO qwk; Info: give w/ food; D/C 4wk after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

malaria tx, uncomplicated

[1000 mg PO x1, then 500 mg PO x1 at 6h, 24h, and 48h]

Info: give w/ food; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine or tafenoquine; refer to CDC guidelines

malaria antirelapse tx (off-label)

[pts w/ G6PD deficiency]

Dose: 500 mg PO qwk x1y; Info: for P. vivax or P. ovale infection; give w/ food; refer to CDC guidelines

[pregnant pts]

Dose: 500 mg PO qwk; Info: for P. vivax or P. ovale infection; may follow-up tx w/ primaquine or tafenoquine after pregnancy, otherwise cont. chloroquine x1y; give w/ food; refer to CDC guidelines

renal dosing

[adjust dose amount]

CrCl <10: decr. usual dose by 50%

HD: decr. usual dose by 50%; no supplement after dialysis; PD: decr. usual dose by 50%; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 250 mg, 500 mg

Special Note

[strength clarification]

Info: 16.7 mg/kg chloroquine phosphate = 10 mg/kg chloroquine base; doses expressed as chloroquine phosphate

malaria prophylaxis

[8.3 mg/kg/dose PO qwk]

Start: 1-2wk before exposure; if starting after exposure, give 8.3 mg/kg/dose PO q6h x2 doses, then 8.3 mg/kg/dose PO qwk; Max: 500 mg/dose Info: give w/ food; D/C 4wk after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

malaria tx, uncomplicated

[16.7 mg/kg/dose PO x1, then 8.3 mg/kg/dose PO x1 at 6h, 24h, and 48h]

Max: 1000 mg for initial dose, 500 mg for subsequent doses; Info: give w/ food; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine or tafenoquine; refer to CDC guidelines

malaria antirelapse tx (off-label)

[pts w/ G6PD deficiency]

Dose: 8.3 mg/kg/dose PO qwk; Max: 500 mg/dose; Info: for P. vivax or P. ovale infection; give w/ food; refer to CDC guidelines

[pregnant pts]

Dose: 8.3 mg/kg/dose PO qwk; Max: 500 mg/dose; Info: for P. vivax or P. ovale infection; may follow-up tx w/ primaquine or tafenoquine after pregnancy, otherwise cont. chloroquine x1y; give w/ food; refer to CDC guidelines

renal dosing

[see below]

CrCl <10: decr. usual dose by 50%

HD/PD: not defined, consider adult renal dosing for guidance

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised