Ancobon

Adult Dosing .

Dosage forms:  CAP: 250 mg, 500 mg

cryptococcal meningitis

[100 mg/kg/day PO divided q6h for at least 2wk]

Info: for induction tx; give w/ other antifungal agents

nonmeningeal cryptococcosis, severe

[100 mg/kg/day PO divided q6h for at least 2wk]

Info: for induction tx; give w/ other antifungal agents

invasive candidiasis, severe

[100 mg/kg/day PO divided q6h]

Info: not 1st-line agent; give w/ other antifungal agents

renal dosing

[see below]

CrCl 21-40: give usual divided dose q12h; CrCl 10-20: give usual divided dose q24h; CrCl <10: give usual divided dose q48h; Info: adjust dose based on serum levels

HD: give usual dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 500-1000 mg q24h; supplement not defined; Info: adjust dose based on serum levels

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  CAP: 250 mg, 500 mg

cryptococcal meningitis (off-label)

[100 mg/kg/day PO divided q6h for at least 2wk]

Info: for induction tx; give w/ other antifungal agents

nonmeningeal cryptococcosis, severe (off-label)

[100 mg/kg/day PO divided q6h for at least 2wk]

Info: for induction tx; give w/ other antifungal agents

invasive candidiasis, severe (off-label)

[100 mg/kg/day PO divided q6h]

Info: not 1st-line agent; give w/ other antifungal agents

renal dosing

[see below]

CrCl 21-40: give usual divided dose q12h; CrCl 10-20: give usual divided dose q24h; CrCl <10: give usual divided dose q48h or consider avoiding use; Info: adjust dose based on serum levels

HD: give usual divided dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: give usual divided dose q48h; supplement not defined; Info: adjust dose based on serum levels

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised