Slo-Niacin

Adult Dosing .

Dosage forms:  ER TAB: 250 mg, 500 mg, 750 mg

Special Note

[formulation clarification]

Info: not interchangeable w/ other niacin ER products; do not substitute on a mg to mg basis

dietary supplementation

[1/2-1 tab PO qd]

Info: do not crush/chew tab; give w/ food; all available ER forms exceed normal upper limit for dietary reference intake; see Dietary Reference Intakes: Vitamin B3 (niacin) table

hypertriglyceridemia, severe (off-label)

[1000-2000 mg PO qhs]

Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food

primary hyperlipidemia (off-label)

[1000-2000 mg PO qhs]

Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: not 1st-line tx; aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food

cardiovascular event risk reduction (off-label)

[1000-2000 mg PO qhs]

Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food

CAD (off-label)

[1000-2000 mg PO qhs]

Start: 500 mg PO qhs x4wk, then incr. 500 mg/day q4wk based on effect/tolerance; Max: 2000 mg/day; Info: use w/ bile acid binding resin; aspirin 325 mg 30min before dose may reduce flushing; do not crush/chew tab; give w/ low-fat food

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic dz hx: not defined, caution advised; unexplained elev. LFTs/active hepatic dz: contraindicated

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.