Zoladex

Adult Dosing .

Dosage forms:  IMPLANT: 3.6 mg, 10.8 mg

prostate CA, stage B2-C

[3.6 mg SC q28 days x4 doses]

Start: 8wk before XRT; Alt: 3.6 mg SC x1, then 28 days later, 10.8 mg SC x1; Info: use w/ flutamide and XRT

advanced prostate CA, palliative tx

[3.6 mg SC q28 days]

Alt: 10.8 mg SC q12wk

advanced breast CA, palliative tx

[3.6 mg SC q28 days]

endometriosis

[3.6 mg SC q28 days x6mo]

endometrial thinning

[3.6 mg SC q28 days x1-2 doses]

Info: for pts w/ dysfunctional uterine bleeding undergoing endometrial ablation

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  IMPLANT: 3.6 mg, 10.8 mg

central precocious puberty (off-label)

[2 yo and older]

Dose: 3.6 mg SC q4wk; Alt: 10.8 mg SC q12wk; Info: consider D/C by 11 yo (girls) or 12 yo (boys)

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance