Activase

Adult Dosing .

Dosage forms:  INJ

acute myocardial infarction

[accelerated infusion, <67 kg]

Dose: 15 mg IV x1, then 0.75 mg/kg/dose IV over 30min, then 0.5 mg/kg/dose IV over 60min; Max: 100 mg/total dose

[accelerated infusion, >67 kg]

Dose: 15 mg IV x1, then 50 mg IV over 30min, then 35 mg IV over 60min; Max: 100 mg/total dose

[3h infusion, <65 kg]

Dose: 0.075 mg/kg/dose IV x1, then 0.675 mg/kg IV over 60min, then 0.5 mg/kg IV over 120min; Max: 100 mg/total dose

[3h infusion, >65 kg]

Dose: 60 mg IV over 60min, then 40 mg IV over 120min; Max: 100 mg/total dose; Info: give 6-10 mg of first dose as bolus, then remainder over 60min

acute ischemic stroke

[0.9 mg/kg/total dose IV over 60min]

Start: ASAP w/in 3h of sx onset; give 10% total dose (0.09 mg/kg/dose) IV x1, then remaining 90% (0.81 mg/kg/dose) IV over 60min; Max: 90 mg/total dose; Info: D/C if pre-tx INR >1.7 or aPTT incr; may give w/in 3-4.5h of sx onset if pt <81 yo w/o diabetes mellitus and prior stroke hx, no anticoagulant use, NIHSS score <26, and ischemic injury <33% MCA territory on imaging

acute massive pulmonary embolism

[100 mg IV over 2h]

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: not defined; severe impairment: not defined, caution advised

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.