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misoprostol
generic
Black Box Warnings .
Pregnancy
use in pregnant women can cause birth defects, abortion, premature birth, or uterine rupture; uterine rupture reported w/ use to induce labor or abortion; risk of uterine rupture incr. w/ advancing gestational age and prior uterine surgery, incl. cesarean delivery; do not use to decr. NSAID ulcer risk in pregnant pts; advise pts of abortifacient property and warn not to give to others
Women of Child-Bearing Potential
do not use to decr. risk of NSAID-induced ulcers in women of child-bearing potential unless high risk of gastric ulcer; in such pts only use if 1) negative serum pregnancy test <2wk prior to start tx, 2) pt capable of complying w/ effective contraception, 3) pt given oral and written warnings of hazards, risk of contraception failure, and danger if taken by other women of child-bearing potential, 4) start med on 2nd or 3rd day of next normal menstrual period
Adult Dosing .
Dosage forms: TAB: 100 mcg, 200 mcg
NSAID GI ulcer prevention
- [100-200 mcg PO qid]
- Info: give w/ meals, last dose at bedtime
constipation, chronic (off-label)
- [600-2400 mcg/day PO divided bid-qid]
- Info: for use in refractory cases; give w/ meals, last dose at bedtime
cervical ripening (off-label)
- [25 mcg PV q3-6h]
- Max: 50 mcg/dose; Info: for use at or near term; wait >4h after last dose before adding oxytocin; for hospital use only
early pregnancy termination (off-label)
- [800 mcg buccally x1]
- Info: pt must be <71 days from 1st day of last menstrual period; use w/in 24-48h of mifepristone per protocol; call Danco Labs 1-877-432-7596 for more info
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.