cimetidine

Adult Dosing .

Dosage forms:  TAB: 200 mg, 300 mg, 400 mg, 800 mg

duodenal ulcer, active

[800 mg PO qhs x4-8wk]

Alt: 1600 mg PO qhs x4wk; 400 mg PO bid x4-6wk; 300 mg PO qid x4-6wk; Max: 1600 mg/day; Info: give daytime doses w/ food

duodenal ulcer, maintenance tx

[400 mg PO qhs]

gastric ulcer, active benign

[800 mg PO qhs x6wk]

Alt: 300 mg PO qid x6wk; Max: 2400 mg/day; Info: give daytime doses w/ food

GERD

[1600 mg/day PO divided bid-qid x12wk]

Info: give daytime doses w/ food

Zollinger-Ellison syndrome

[300-600 mg PO qid]

Max: 2400 mg/day; Info: give daytime doses w/ food

renal dosing

[adjust dose amount]

CrCl 10-50: decr. usual dose by 50%; CrCl <10: decr. usual dose by 75%

HD: decr. usual dose by 75%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 75%; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 200 mg, 300 mg, 400 mg; SOL: 300 mg per 5 mL

GERD/PUD (off-label)

[neonates]

Dose: 5-10 mg/kg/day PO divided q8-12h; Info: give daytime doses w/ food

[infants]

Dose: 10-20 mg/kg/day PO divided q6-12h; Info: give daytime doses w/ food

[children]

Dose: 20-40 mg/kg/day PO divided q6h; Info: give daytime doses w/ food

renal dosing

[see below]

CrCl 20-40: decr. usual dose by 25%; CrCl <20: decr. usual dose by 50%

HD: give usual dose q12h, on dialysis days admin. after dialysis; no supplement; PD: give usual dose q12h; no supplement

hepatic dosing

[not defined]