cyanocobalamin (vitamin B12)

Adult Dosing .

Dosage forms:  CAP: 1000 mcg, 3000 mcg, 5000 mcg; TAB: 50 mcg, 100 mcg, 250 mcg, 500 mcg, 1000 mcg, 2000 mcg, 2500 mcg; ER TAB: 1000 mcg, 1500 mcg, 5000 mcg; ODT: 1500 mcg; SL TAB: 500 mcg, 1000 mcg, 2500 mcg, 3000 mcg, 5000 mcg, 6000 mcg; CHEWABLE: 250 mcg, 500 mcg, 750 mcg; SL SOL: 5000 mcg per mL; INJ: 1000 mcg per mL

Schilling test flushing dose

[1000 mcg IM x1]

vitamin B12 deficiency

[initial tx]

Dose: 1000 mcg SC/IM qd x1wk, then qwk x1mo, then maintenance tx; Alt: 100 mcg SC/IM qd x1wk, then qod x2wk, then q3-4 days x2-3wk or until complete remission, then maintenance tx; Info: give intradermal test dose before use if hypersensitivity risk

[maintenance tx]

Dose: 1000 mcg SC/IM qmo; Alt: 500-2000 mcg PO/SL qd; Info: give PO on empty stomach to enhance absorption

dietary supplementation

[individualize dose]

Info: see Dietary Reference Intakes: Vitamin B12 (cobalamin) table

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ: 1000 mcg per mL

pernicious anemia

[initial tx]

Dose: 30-50 mcg SC/IM qd x14 days, then maintenance tx; Alt: 1000 mcg SC/IM qd x2-7 days, then maintenance tx; Info: give intradermal test dose before use if hypersensitivity risk

[maintenance tx]

Dose: 100 mcg SC/IM qmo

vitamin B12 deficiency

[initial tx]

Start: 100 mcg SC/IM qd x10-15 days, then maintenance tx; Alt: 1000 mcg SC/IM qd x2-7 days, then maintenance tx; Info: give intradermal test dose before use if hypersensitivity risk

[maintenance tx]

Dose: 60-100 mcg SC/IM qmo

dietary supplementation

[individualize dose]

Info: see Dietary Reference Intakes: Vitamin B12 (cobalamin) table

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]