dapsone

Adult Dosing .

Dosage forms:  TAB: 25 mg, 100 mg

leprosy (Hansen dz), paucibacillary

[100 mg PO qd x6mo]

Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 6mo in non-resistant refractory cases

leprosy (Hansen dz), multibacillary

[100 mg PO qd x12mo]

Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 12mo in non-resistant refractory cases

dermatitis herpetiformis

[50 mg PO qd]

PCP prophylaxis (off-label)

[monotherapy]

Dose: 100 mg/day PO divided qd-bid; Info: not 1st-line agent

[combo tx w/ pyrimethamine, leucovorin]

Dose: 50 mg PO qd; Alt: 200 mg PO qwk; Info: not 1st-line agent

PCP tx, mild-mod. (off-label)

[100 mg PO qd x21 days]

Info: not 1st-line agent; give w/ trimethoprim

toxoplasmosis prophylaxis, primary (off-label)

[50 mg PO qd]

Alt: 200 mg PO qwk; Info: not 1st-line agent; give w/ pyrimethamine, leucovorin

renal dosing

[no adjustment]

renal impairment: no adjustment

HD: no adjustment, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 25 mg, 100 mg

leprosy (Hansen dz), paucibacillary

[<10 yo]

Dose: 2 mg/kg/dose PO qd x6mo; Max: 50 mg/dose; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 6mo in non-resistant refractory cases

[10-14 yo]

Dose: 50 mg PO qd x6mo; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 6mo in non-resistant refractory cases

[15 yo and older]

Dose: 100 mg PO qd x6mo; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 6mo in non-resistant refractory cases

leprosy (Hansen dz), multibacillary

[<10 yo]

Dose: 2 mg/kg/dose PO qd x12mo; Max: 50 mg/dose; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 12mo in non-resistant refractory cases

[10-14 yo]

Dose: 50 mg PO qd x12mo; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 12mo in non-resistant refractory cases

[15 yo and older]

Dose: 100 mg PO qd x12mo; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 12mo in non-resistant refractory cases

PCP prophylaxis (off-label)

[1 mo and older]

Dose: 2 mg/kg/dose PO qd; Alt: 4 mg/kg/dose PO qwk; Max: 100 mg/dose if qd, 200 mg/dose if qwk; Info: not 1st-line agent

toxoplasmosis prophylaxis, primary (off-label)

[1 mo and older]

Dose: 2 mg/kg/dose PO qd; Alt: 15 mg/m^2/dose PO qd; Max: 25 mg/day; Info: not 1st-line agent; give w/ pyrimethamine, leucovorin

renal dosing

[no adjustment]

renal impairment: no adjustment

HD: no adjustment, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised