thiamine (vitamin B1)

Adult Dosing .

Dosage forms:  TAB: 50 mg, 100 mg, 250 mg, 500 mg; INJ: various

beriberi

[100-200 mg IV/PO qd-tid x2-3 days, then 10 mg PO qd for at least 1mo]

Alt: 50 mg IM qd x2-4 days, then 10 mg PO qd for at least 1mo; Info: give intradermal skin test before use if hypersensitivity risk (IV/IM)

Wernicke encephalopathy

[200-500 mg IV tid x2-7 days, then 250 mg IV/IM qd x3-5 days]

Info: give intradermal skin test before use if hypersensitivity risk (IV/IM); may follow w/ 100 mg PO qd

Wernicke encephalopathy prevention

[100-200 mg IV x1-3 doses]

Info: for pts at high risk of thiamine deficiency; give w/ first few liters IV dextrose to avoid precipitating heart failure; give intradermal skin test before use if hypersensitivity risk (IV/IM)

neuritis, pregnant pts

[5-10 mg IM qd]

Info: for pts w/ severe vomiting

dietary supplementation

[individualize dose]

Info: see Dietary Reference Intakes: Vitamin B1 (thiamine) table

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 50 mg, 100 mg; INJ: various

beriberi

[10-50 mg PO qd x2wk, then 5-10 mg PO qd x1 mo]

Info: start 10-25 mg IV/IM qd in critically ill pts; give intradermal skin test before use if hypersensitivity risk (IV/IM)

dietary supplementation

[individualize dose]

Info: see Dietary Reference Intakes: Vitamin B1 (thiamine) table

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]