phenylephrine injection

Adult Dosing .

Dosage forms:  INJ: 10 mg per mL

shock

[40-60 mcg/min IV]

Start: 100-180 mcg/min IV until BP stable; Alt: 0.5-6 mcg/kg/min IV, titrate to BP goal

hypotension, anesthesia-associated

[bolus regimen]

Dose: 50-100 mcg IV x1; Max: 200 mcg/total dose; Info: may repeat q1-2min prn

[continuous infusion]

Dose: 10-35 mcg/min IV; Max: 200 mcg/min; Alt: 0.5-1.4 mcg/kg/min IV

post-resuscitation stabilization (off-label)

[0.5-2 mcg/kg/min IV]

Info: refer to ACLS guidelines

rapid sequence intubation adjunct (off-label)

[50-100 mcg IV x1]

Max: 200 mcg/total dose; Info: for pts w/ shock or s/sx hypotension during intubation; see Rapid Sequence Intubation (RSI), Adult table

priapism (off-label)

[1 mL (100-500 mcg/mL) intracavernously q3-5min for up to 1h]

Max: 1000 mcg/h; Info: dilute w/ NS to conc. 100-500 mcg/mL; use lower conc. or volume in pts w/ severe CVD

renal dosing

[see below]

renal impairment: not defined; Info: consider decr. usual dose if ESRD

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class A, B, or C: consider incr. usual dose

Peds Dosing .

Dosage forms:  INJ: 10 mg per mL

shock (off-label)

[2-12 yo]

Dose: 0.1-0.5 mcg/kg/min IV, titrate to BP goal; Max: 3-5 mcg/kg/min; Alt: start 5-20 mcg/kg/dose up to 500 mcg IV x1, then 5-20 mcg/kg/dose up to 1000 mcg/dose IV q10-15min prn

hypotension, spinal anesthesia-associated (off-label)

[2-12 yo]

Dose: 44-88 mcg/kg/dose SC/IM x1

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance