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Nimbex
cisatracurium
Adult Dosing .
Dosage forms: INJ
neuromuscular blockade induction
- [150-200 mcg/kg/dose IV x1]
- Info: onset 1.5-2min, duration 55-61min (intermediate-acting); max initial bolus 20 mcg/kg/dose if neuromuscular dz; consider extended interval between dose admin. and intubation by at least 1min in elderly pts
neuromuscular blockade maintenance
- [intermittent IV]
- Dose: 30 mcg/kg/dose IV q20min prn; Start: 40-60min after 150 mcg/kg induction dose, 50-60min after 200 mcg/kg induction dose
- [continuous IV]
- Dose: 1-2 mcg/kg/min IV; Start: 3 mcg/kg/min IV after spontaneous recovery from induction dose; Info: rates may vary widely between 0.5-10 mcg/kg/min; decr. rate 30-40% if under isoflurane or enflurane anesthesia, 50% if undergoing CABG w/ induced hypothermia
renal dosing
- [see below]
- renal impairment: not defined; Info: consider extended interval between dose admin. and intubation by at least 1min if end-stage renal dz
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined; Info: onset 1min faster in end-stage hepatic dz vs. healthy pts
Peds Dosing .
- Dosage forms: INJ
neuromuscular blockade induction
- [1-23 mo]
- Dose: 150 mcg/kg/dose IV x1; Info: onset 2min, duration 43min (intermediate-acting); max initial bolus 20 mcg/kg/dose if neuromuscular dz
- [2-12 yo]
- Dose: 100-150 mcg/kg/dose IV x1; Info: onset 2.8-3min, duration 28-36min (intermediate-acting); max initial bolus 20 mcg/kg/dose if neuromuscular dz
- [>12 yo]
- Dose: 150-200 mcg/kg/dose IV x1; Info: onset 1.5-2min, duration 55-61min (intermediate-acting); max initial bolus 20 mcg/kg/dose if neuromuscular dz
neuromuscular blockade maintenance
- [2 yo and older]
- Dose: 1-2 mcg/kg/min IV; Start: 3 mcg/kg/min IV after spontaneous recovery from induction dose; Info: rates may vary widely between 0.5-10 mcg/kg/min; decr. rate 30-40% if under isoflurane or enflurane anesthesia
renal dosing
- [see below]
- renal impairment: not defined; Info: consider extended interval between dose admin. and intubation by at least 1min if end-stage renal dz
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined; Info: onset 1min faster in end-stage hepatic dz vs. healthy pts