propofol

Adult Dosing .

Dosage forms:  INJ

general anesthesia induction

[<65 yo, American Society of Anesthesiologists physical status I-II pts]

Dose: 2-2.5 mg/kg/dose IV given as 40 mg IV q10sec until induction onset; Info: use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

[>65 yo, debilitated, or American Society of Anesthesiologists physical status III-IV pts]

Dose: 1-1.5 mg/kg/dose IV given as 20 mg IV q10sec until induction onset; Info: use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

[neurosurgical pts]

Dose: 1-2 mg/kg/dose IV given as 20 mg IV q10sec until induction onset; Info: use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

[cardiac anesthesia pts]

Dose: 0.5-1.5 mg/kg/dose IV given as 20 mg IV q10sec until induction onset; Info: use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

general anesthesia maintenance

[<65 yo, American Society of Anesthesiologists physical status I-II pts]

Dose: 100-200 mcg/kg/min IV; Alt: 20-50 mg IV x1 prn; Info: use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

[>65 yo, debilitated, or American Society of Anesthesiologists physical status III-IV pts]

Dose: 50-100 mcg/kg/min IV; Info: use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

[neurosurgical pts]

Dose: 100-200 mcg/kg/min IV; Info: use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

[cardiac anesthesia pts]

Dose: 25-100 mcg/kg/min IV; Info: use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

monitored anesthesia care induction

[100-150 mcg/kg/min IV x3-5min]

Alt: 0.5 mg/kg/dose IV x1; Info: use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

monitored anesthesia care maintenance

[25-75 mcg/kg/min IV]

Alt: 10-20 mg IV x1 prn; Info: avoid bolus doses and decr. dose by 20% in elderly, debilitated, neurosurgical, or American Society of Anesthesiologists physical status III-IV pts; use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

ICU sedation

[5-50 mcg/kg/min IV]

Start: 5 mcg/kg/min IV x5min, then may incr. by 5-10 mcg/kg/min q5-10min; Info: for intubated, mechanically ventilated pts; use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

rapid sequence intubation (off-label)

[1-3 mg/kg/dose IV x1]

Start: 3min after premedications; Info: see Rapid Sequence Intubation (RSI), Adult table

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

general anesthesia induction

[3-16 yo, American Society of Anesthesiologists physical status I-II pts]

Dose: 2.5-3.5 mg/kg/dose IV x1; Info: use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese; decr. dose if American Society of Anesthesiologists physical status III-IV pts

general anesthesia maintenance

[2 mo-16 yo, American Society of Anesthesiologists physical status I-II pts]

Dose: 125-300 mcg/kg/min IV; Alt: 1-4 mg/kg/dose IV x1, then 0.5-2 mg/kg/dose IV x1 prn; Info: use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

sedation, procedural (off-label)

[1-18 yo]

Dose: 1 mg/kg/dose IV x1, then 0.5 mg/kg/dose IV x1 prn; Max: 40 mg initial dose then 20 mg/dose; Info: pretreat w/ oxygen; premedicate w/ fentanyl or morphine; use adjusted wt of IBW + 0.4 x (ABW - IBW) if obese

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]