Select a medication above to begin.
Novolin R
insulin regular
Adult Dosing .
Dosage forms: INJ (FlexPen U-100 pen, FlexPen ReliOn U-100 pen): 100 units per mL; INJ (U-100 vial, ReliOn U-100 vial): 100 units per mL
Special Note
- [additional info]
- Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility
diabetes mellitus, type 1
- [SC route]
- Dose: individualize dose SC bid-qid; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); give 30min before meals; use w/ intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.5-1h, peak 2-4h, duration 6-12h (short-acting insulin)
- [IV route]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)
diabetes mellitus, type 2
- [SC route]
- Dose: individualize dose SC bid-qid; Start: 4 units SC qd or 10% of basal insulin dose SC qd, may incr. dose by 1-2 units or 10-15% 2x/wk; Info: give 30min before meals; use w/ intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.5-1h, peak 2-4h, duration 6-12h (short-acting insulin)
- [IV route]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)
diabetic ketoacidosis (off-label)
- [individualize dose via IV infusion]
- Start: 0.1 units/kg/h IV; Info: may give 0.1 units/kg/dose IV x1 if infusion delay; when blood glucose <250 mg/dL, decr. dose to 0.05 units/kg/h IV and add dextrose 5-10%; maintain blood glucose at 150-200 mg/dL until DKA resolves; start insulin SC injection >1-2h before D/C insulin IV; refer to institutional protocol
hyperglycemic hyperosmolar state (off-label)
- [individualize dose via IV infusion]
- Start: 0.05-0.1 units/kg/h IV; Info: when blood glucose <250 mg/dL, decr. dose to 0.05 units/kg/h IV and add dextrose 5-10%; maintain blood glucose at 200-250 mg/dL until HHS resolves; start insulin SC injection >1-2h before D/C insulin IV; refer to institutional protocol
hyperkalemia (off-label)
- [10 units IV x1]
- Info: give w/ D50W
renal dosing
- [see below]
- renal impairment: consider decr. usual start dose
- HD/PD: consider decr. usual start dose; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: INJ (FlexPen U-100 pen, FlexPen ReliOn U-100 pen): 100 units per mL; INJ (U-100 vial, ReliOn U-100 vial): 100 units per mL
Special Note
- [additional info]
- Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility
diabetes mellitus, type 1
- [SC route]
- Dose: individualize dose SC bid-qid; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; give 30min before meals; use w/ intermediate-acting or long-acting insulin; onset 0.5-1h, peak 2-4h, duration 6-12h (short-acting insulin)
- [IV route]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)
diabetes mellitus, type 2
- [SC route]
- Dose: individualize dose SC bid-qid; Info: give 30min before meals; use w/ intermediate-acting or long-acting insulin; onset 0.5-1h, peak 2-4h, duration 6-12h (short-acting insulin)
- [IV route]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; onset 0.25h, peak 0.25-0.5h, duration 0.5-1h (short-acting insulin)
diabetic ketoacidosis (off-label)
- [IV route]
- Dose: 0.05-0.1 units/kg/h IV; Start: 1h after initial fluid tx; Info: for pts w/ marked insulin sensitivity, may decr. dose to <0.05 units/kg/h IV; add dextrose 5% when blood glucose 250-300 mg/dL or if blood glucose decr. at rate >90 mg/dL/h; maintain blood glucose at 200 mg/dL until DKA resolves; start insulin SC injection adequate interval before D/C insulin IV; refer to institutional protocol
- [SC route]
- Dose: individualize dose SC q2-4h; Start: 0.13-0.17 units/kg/dose SC q4h 1h after initial fluid tx, then may adjust dose by 10-20%; Info: for pts w/ mild DKA; add dextrose 5% when blood glucose 250-300 mg/dL or if blood glucose decr. at rate >90 mg/dL/h; maintain blood glucose at 200 mg/dL until DKA resolves; refer to institutional protocol
hyperkalemia (off-label)
- [<1 mo]
- Dose: 0.1-0.2 units/kg/h IV; Info: give w/ dextrose; refer to institution protocol
- [1 mo and older]
- Dose: 0.05-0.1 units/kg/h IV; Info: give w/ dextrose; refer to institution protocol
renal dosing
- [see below]
- renal impairment: consider decr. usual start dose
- HD/PD: consider decr. usual start dose; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised