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Ziagen
abacavir
Black Box Warnings .
Hypersensitivity Rxn
serious or fatal hypersensitivity rxn have occurred w/ abacavir-containing products; abacavir hypersensitivity is a multi-organ clinical syndrome; HLA-B*57:01 allele carriers at higher risk of hypersensitivity rxns; abacavir contraindicated in HLA-B*57:01-positive pts or in pts w/ prior hypersensitivity rxn to abacavir; permanently D/C if hypersensitivity rxn suspected or cannot be ruled out, regardless of HLA-B*57:01 status; NEVER restart any abacavir-containing products after hypersensitivity rxn
Adult Dosing .
Dosage forms: SOL: 20 mg per mL
HIV infection
- [300 mg PO bid]
- Alt: 600 mg PO qd; Info: D/C drug and do not restart if hypersensitivity rxn suspected
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- Child-Pugh Class A: 200 mg bid; Child-Pugh Class B or C: contraindicated
Peds Dosing .
- Dosage forms: SOL: 20 mg per mL
HIV infection
- [<1 mo (off-label)]
- Dose: 4 mg/kg/day PO divided bid; Max: 600 mg/day; Info: for full-term infants; D/C drug and do not restart if hypersensitivity rxn suspected
- [1-2 mo (off-label)]
- Dose: 8 mg/kg/day PO divided bid; Max: 600 mg/day; Info: for full-term infants; D/C drug and do not restart if hypersensitivity rxn suspected
- [3 mo and older, <20 kg]
- Dose: 16 mg/kg/day PO divided qd-bid; Max: 600 mg/day; Info: may give 300 mg tab PO qd or 150 mg tab PO bid if wt >14 kg; D/C drug and do not restart if hypersensitivity rxn suspected
- [3 mo and older, 20-24 kg]
- Dose: 16 mg/kg/day PO divided qd-bid; Max: 600 mg/day; Alt: 450 mg PO qd; 150 mg PO qam, 300 mg PO qpm; Info: D/C drug and do not restart if hypersensitivity rxn suspected
- [3 mo and older, >25 kg]
- Dose: 16 mg/kg/day PO divided qd-bid; Max: 600 mg/day; Alt: 600 mg PO qd; 300 mg PO bid; Info: D/C drug and do not restart if hypersensitivity rxn suspected
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance