Select a medication above to begin.
Actos
pioglitazone
Black Box Warnings .
Congestive Heart Failure
thiazolidinediones cause or exacerbate CHF; observe pts closely after tx initiation or dose incr. for s/sx incl. excessive, rapid wt gain, dyspnea, and/or edema; manage CHF based on current care standards if s/sx develop and consider D/C or dose reduction; contraindicated in pts w/ NYHA Class III-IV CHF and not recommended in pts w/ symptomatic CHF
Adult Dosing .
Dosage forms: TAB: 15 mg, 30 mg, 45 mg
diabetes mellitus, type 2
- [15-45 mg PO qd]
- Start: 15-30 mg PO qd; Max: 45 mg/day
metabolic dysfxn-associated steatohepatitis, DM type 2 pts (off-label)
- [15-45 mg PO qd]
- Start: 15-30 mg PO qd; Max: 45 mg/day; Info: for pts w/ biopsy-proven metabolic dysfxn-associated steatohepatitis
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: TAB: 15 mg, 30 mg, 45 mg
diabetes mellitus, type 2 (off-label)
- [>15 yo]
- Dose: 15-30 mg PO qd; Start: 15 mg PO qd; Max: 45 mg/day; Info: give w/ metformin
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised