Aciphex

Adult Dosing .

Dosage forms:  DR TAB: 20 mg

GERD

[non-erosive, symptomatic]

Dose: 20 mg PO qd x4-8wk; Info: do not cut/crush/chew tab

[erosive esophagitis, short-term tx]

Dose: 20 mg PO qd x4-16wk; Info: do not cut/crush/chew tab

[erosive esophagitis, maintenance tx]

Dose: 20 mg PO qd; Info: do not cut/crush/chew tab

duodenal ulcer

[20 mg PO qd x4wk]

Info: may repeat x4wk if needed; give after meals; do not cut/crush/chew tab

hypersecretory conditions

[individualize dose PO qd-bid]

Start: 60 mg PO qd; Info: doses up to 100 mg PO qd and 60 mg PO bid have been used; do not cut/crush/chew tab

H. pylori infection

[20-40 mg PO bid x14 days]

Info: part of multi-drug regimen, dosing may vary; give before meals; do not cut/crush/chew tab; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  DR TAB: 20 mg

GERD

[non-erosive symptomatic, 12 yo and older]

Dose: 20 mg PO qd x4-8wk; Info: do not cut/crush/chew tab

[erosive esophagitis short-term tx, 12 yo and older]

Dose: 20 mg PO qd x4-16wk; Info: for short-term and maintenance tx; do not cut/crush/chew tab

[erosive esophagitis maintenance tx, 12 yo and older]

Dose: 20 mg PO qd; Info: for short-term and maintenance tx; do not cut/crush/chew tab

H. pylori infection (off-label)

[15-24 kg]

Dose: 20 mg PO bid x10-14 days; Info: part of multi-drug regimen; give >15min before meals; do not cut/crush/chew tab; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

[25-34 kg]

Dose: 30 mg PO bid x10-14 days; Info: part of multi-drug regimen; give >15min before meals; do not cut/crush/chew tab; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

[>35 kg]

Dose: 40 mg PO bid x10-14 days; Info: part of multi-drug regimen; give >15min before meals; do not cut/crush/chew tab; search 'H. pylori Tx' for epocrates H. pylori Tx Regimens decision tool

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined, caution advised