Select a medication above to begin.
Enbrel
etanercept
Black Box Warnings .
Serious Infection Risk
weigh tx benefit vs. risk in pts w/ chronic or recurrent infection; pulmonary and extrapulmonary tuberculosis (TB), invasive fungal infections, and other opportunistic infections incl. Legionella and Listeria observed; some infections have been fatal; most infections occur in combo w/ other immunosuppressants; evaluate for TB risk factors and screen for latent TB infection before and during etanercept tx; initiate anti-TB tx before etanercept tx; monitor for infection s/sx during and after etanercept tx; since active TB has developed in pts w/ negative tuberculin skin test, monitor all pts for active TB s/sx; since histoplasmosis may be present in pts w/ negative antigen and antibody tests, consider empiric antifungal tx in pts w/ severe systemic illness if at risk for invasive fungal infection; D/C etanercept tx if serious infection or sepsis occurs
Malignancy
lymphoma and other malignancies, some fatal, reported in children and adolescents treated w/ TNF blockers
Adult Dosing .
Dosage forms: INJ (SureClick auto-injector): 50 mg; INJ (Mini cartridge): 50 mg; INJ (pre-filled syringe): 25 mg per 0.5 mL, 50 mg per mL; INJ (vial): 25 mg per mL, 25 mg per 0.5 mL
rheumatoid arthritis, mod-severe
- [50 mg SC qwk]
- Alt: 25 mg SC 2x/wk 72-96h apart
psoriatic arthritis
- [50 mg SC qwk]
- Alt: 25 mg SC 2x/wk 72-96h apart
ankylosing spondylitis
- [50 mg SC qwk]
- Alt: 25 mg SC 2x/wk 72-96h apart
psoriasis, mod-severe chronic plaque
- [50 mg SC qwk]
- Start: 50 mg SC 2x/wk x3mo; Alt: 25 mg SC 2x/wk 72-96h apart
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ (SureClick auto-injector): 50 mg; INJ (Mini cartridge): 50 mg; INJ (pre-filled syringe): 25 mg per 0.5 mL, 50 mg per mL; INJ (vial): 25 mg per mL, 25 mg per 0.5 mL
polyarticular juvenile idiopathic arthritis, moderate-severe
- [2-17 yo, <63 kg]
- Dose: 0.8 mg/kg/dose SC qwk; Max: 50 mg/wk; Alt: 0.4 mg/kg/dose SC 2x/wk 72-96h apart
- [2-17 yo, >63 kg]
- Dose: 50 mg SC qwk; Alt: 25 mg SC 2x/wk 72-96h apart
psoriasis, mod-severe chronic plaque
- [4-17 yo, <63 kg]
- Dose: 0.8 mg/kg/dose SC qwk; Max: 50 mg/wk; Alt: 0.4 mg/kg/dose SC 2x/wk 72-96h apart
- [4-17 yo, >63 kg]
- Dose: 50 mg SC qwk; Alt: 25 mg SC 2x/wk 72-96h apart
psoriatic arthritis
- [2-17 yo, <63 kg]
- Dose: 0.8 mg/kg/dose SC qwk; Max: 50 mg/wk; Alt: 0.4 mg/kg/dose SC 2x/wk 72-96h apart
- [2-17 yo, >63 kg]
- Dose: 50 mg SC qwk; Alt: 25 mg SC 2x/wk 72-96h apart
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]