Hectorol

Adult Dosing .

Dosage forms:  INJ

Dosage Forms Discontinued in US

[cap not avail. as brand; see generic]

hyperparathyroidism, secondary

[CKD stage 3 not on dialysis]

Dose: individualize dose PO qd; Start: 1 mcg PO qd, then may adjust by 0.5 mcg/day q2wk; Max: 3.5 mcg/day; Info: routine use not recommended, refer to KDIGO guidelines; see pkg insert for dose adjustments based on iPTH, Ca, PO4 levels; restart at lower dose after D/C x1wk

[CKD stage 4 or 5 not on dialysis]

Dose: individualize dose PO qd; Start: 1 mcg PO qd, then may adjust by 0.5 mcg/day q2wk; Max: 3.5 mcg/day; Info: for pts w/ severe or progressive hyperparathyroidism; see pkg insert for dose adjustments based on iPTH, Ca, PO4 levels; restart at lower dose after D/C x1wk

[CKD stage 5 on dialysis, PO route]

Dose: individualize dose PO 3x/wk on dialysis days; Start: 10 mcg PO 3x/wk on dialysis days, then may adjust by 2.5 mcg/dose q8wk; Max: 20 mcg/dose up to 60 mcg/wk; Info: admin. during dialysis; see pkg insert for dose adjustments based on iPTH, Ca, PO4 levels; dose no more frequently than qod; restart at dose at least 2.5 mcg lower after D/C x1wk

[CKD stage 5 on dialysis, IV route]

Dose: individualize dose IV 3x/wk on dialysis days; Start: 4 mcg IV 3x/wk on dialysis days, then may adjust by 1-2 mcg/dose q8wk; Max: 18 mcg/wk; Info: admin. after dialysis; see pkg insert for dose adjustments based on iPTH, Ca, PO4 levels; dose no more frequently than qod; restart at dose at least 1 mcg lower after D/C x1wk

renal dosing

[see below]

CKD stage 3-5: no adjustment; Info: not defined if CKD stage 1-2

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.